Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| pericyte | 40 studies | 65% ± 20% | |
| fibroblast | 39 studies | 33% ± 12% | |
| smooth muscle cell | 26 studies | 47% ± 18% | |
| myofibroblast cell | 10 studies | 31% ± 18% | |
| astrocyte | 10 studies | 37% ± 15% | |
| endothelial cell | 8 studies | 41% ± 15% | |
| connective tissue cell | 8 studies | 38% ± 11% | |
| adventitial cell | 5 studies | 24% ± 4% | |
| Mueller cell | 3 studies | 25% ± 11% | |
| chondrocyte | 3 studies | 26% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| heart | 4 studies | 16% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 31588.61 | 459 / 459 | 98% | 106.38 | 1093 / 1118 |
| lung | 100% | 27720.99 | 577 / 578 | 94% | 61.37 | 1091 / 1155 |
| prostate | 98% | 17237.15 | 239 / 245 | 88% | 38.87 | 442 / 502 |
| thymus | 99% | 20580.42 | 649 / 653 | 79% | 35.85 | 479 / 605 |
| esophagus | 85% | 12425.28 | 1226 / 1445 | 93% | 74.80 | 170 / 183 |
| skin | 95% | 21518.99 | 1722 / 1809 | 80% | 40.12 | 377 / 472 |
| bladder | 100% | 16691.95 | 21 / 21 | 74% | 40.18 | 375 / 504 |
| intestine | 87% | 10576.05 | 840 / 966 | 87% | 56.79 | 458 / 527 |
| uterus | 100% | 34280.50 | 170 / 170 | 71% | 43.15 | 324 / 459 |
| kidney | 96% | 12854.99 | 85 / 89 | 72% | 84.15 | 648 / 901 |
| ovary | 100% | 29064.93 | 180 / 180 | 63% | 26.96 | 269 / 430 |
| adrenal gland | 80% | 6549.04 | 206 / 258 | 80% | 42.49 | 185 / 230 |
| stomach | 53% | 5600.97 | 192 / 359 | 92% | 72.57 | 262 / 286 |
| brain | 32% | 1932.97 | 834 / 2642 | 94% | 37.81 | 661 / 705 |
| pancreas | 24% | 1582.12 | 80 / 328 | 96% | 131.85 | 170 / 178 |
| adipose | 100% | 43047.36 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 45297.71 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 98% | 11961.44 | 237 / 241 | 0% | 0 | 0 / 0 |
| heart | 98% | 11673.19 | 841 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 83% | 30.44 | 24 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 76% | 39.31 | 34 / 45 |
| liver | 5% | 389.70 | 12 / 226 | 69% | 30.15 | 282 / 406 |
| muscle | 73% | 5389.15 | 583 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 30% | 7.01 | 24 / 80 |
| peripheral blood | 0% | 6.37 | 1 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0032956 | Biological process | regulation of actin cytoskeleton organization |
| GO_0001525 | Biological process | angiogenesis |
| GO_0035441 | Biological process | cell migration involved in vasculogenesis |
| GO_0046488 | Biological process | phosphatidylinositol metabolic process |
| GO_0007169 | Biological process | cell surface receptor protein tyrosine kinase signaling pathway |
| GO_0050850 | Biological process | positive regulation of calcium-mediated signaling |
| GO_0050921 | Biological process | positive regulation of chemotaxis |
| GO_0048661 | Biological process | positive regulation of smooth muscle cell proliferation |
| GO_0007165 | Biological process | signal transduction |
| GO_0007275 | Biological process | multicellular organism development |
| GO_0038091 | Biological process | positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway |
| GO_0060981 | Biological process | cell migration involved in coronary angiogenesis |
| GO_0014911 | Biological process | positive regulation of smooth muscle cell migration |
| GO_0055003 | Biological process | cardiac myofibril assembly |
| GO_0061298 | Biological process | retina vasculature development in camera-type eye |
| GO_0035791 | Biological process | platelet-derived growth factor receptor-beta signaling pathway |
| GO_0048008 | Biological process | platelet-derived growth factor receptor signaling pathway |
| GO_0035793 | Biological process | positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway |
| GO_0043406 | Biological process | positive regulation of MAP kinase activity |
| GO_0033674 | Biological process | positive regulation of kinase activity |
| GO_0072277 | Biological process | metanephric glomerular capillary formation |
| GO_0018108 | Biological process | peptidyl-tyrosine phosphorylation |
| GO_0045840 | Biological process | positive regulation of mitotic nuclear division |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_2000379 | Biological process | positive regulation of reactive oxygen species metabolic process |
| GO_2000573 | Biological process | positive regulation of DNA biosynthetic process |
| GO_0035909 | Biological process | aorta morphogenesis |
| GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0071670 | Biological process | smooth muscle cell chemotaxis |
| GO_0032516 | Biological process | positive regulation of phosphoprotein phosphatase activity |
| GO_0046777 | Biological process | protein autophosphorylation |
| GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
| GO_0060326 | Biological process | cell chemotaxis |
| GO_0036120 | Biological process | cellular response to platelet-derived growth factor stimulus |
| GO_0090280 | Biological process | positive regulation of calcium ion import |
| GO_0072262 | Biological process | metanephric glomerular mesangial cell proliferation involved in metanephros development |
| GO_0016324 | Cellular component | apical plasma membrane |
| GO_0043235 | Cellular component | receptor complex |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0031410 | Cellular component | cytoplasmic vesicle |
| GO_0016020 | Cellular component | membrane |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0005925 | Cellular component | focal adhesion |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0043202 | Cellular component | lysosomal lumen |
| GO_0005634 | Cellular component | nucleus |
| GO_0019899 | Molecular function | enzyme binding |
| GO_0005161 | Molecular function | platelet-derived growth factor receptor binding |
| GO_0038085 | Molecular function | vascular endothelial growth factor binding |
| GO_0004992 | Molecular function | platelet activating factor receptor activity |
| GO_0004713 | Molecular function | protein tyrosine kinase activity |
| GO_0019901 | Molecular function | protein kinase binding |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0005017 | Molecular function | platelet-derived growth factor receptor activity |
| GO_0004672 | Molecular function | protein kinase activity |
| GO_0048407 | Molecular function | platelet-derived growth factor binding |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005019 | Molecular function | platelet-derived growth factor beta-receptor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | PDGFRB |
| Protein name | Platelet derived growth factor receptor beta Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b) |
| Synonyms | PDGFR1 PDGFR |
| Description | FUNCTION: Tyrosine-protein kinase that acts as a cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. . |
| Accessions | E5RH16 E5RJ14 ENST00000517488.1 ENST00000520579.5 ENST00000261799.9 [P09619-1] ENST00000517957.1 P09619 E5RII0 |
