NPR3 | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	6 studies	22% ± 7%	Explore
endothelial cell of artery	5 studies	31% ± 6%	Explore
hematopoietic stem cell	4 studies	47% ± 16%	Explore
hematopoietic precursor cell	3 studies	44% ± 13%	Explore
epithelial cell of proximal tubule	3 studies	27% ± 7%	Explore
retinal ganglion cell	3 studies	36% ± 13%	Explore
capillary endothelial cell	3 studies	24% ± 7%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	48% ± 15%	Explore
parietal epithelial cell	3 studies	30% ± 9%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of NPR3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	100%	4787.08	89 / 89	88%	63.53	794 / 901
lung	100%	2947.56	576 / 578	64%	8.64	735 / 1155
prostate	87%	1044.62	213 / 245	74%	19.31	370 / 502
thymus	98%	2068.49	643 / 653	49%	7.41	298 / 605
adrenal gland	87%	883.50	225 / 258	38%	6.31	88 / 230
uterus	81%	758.28	138 / 170	32%	3.09	145 / 459
breast	62%	1075.37	285 / 459	42%	5.38	468 / 1118
skin	97%	1917.92	1749 / 1809	5%	0.89	23 / 472
blood vessel	98%	2502.20	1312 / 1335	0%	0	0 / 0
liver	67%	489.75	152 / 226	24%	2.22	99 / 406
adipose	90%	2499.92	1088 / 1204	0%	0	0 / 0
ovary	55%	408.82	99 / 180	35%	3.63	149 / 430
heart	89%	2065.05	767 / 861	0%	0	0 / 0
esophagus	48%	522.55	692 / 1445	40%	5.98	74 / 183
intestine	71%	1122.45	689 / 966	12%	1.38	65 / 527
spleen	83%	1297.06	200 / 241	0%	0	0 / 0
bladder	62%	443.81	13 / 21	13%	1.35	66 / 504
pancreas	2%	12.23	8 / 328	67%	8.75	120 / 178
muscle	52%	911.57	419 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	36%	4.26	16 / 45
stomach	24%	140.47	87 / 359	8%	0.43	22 / 286
brain	2%	9.62	61 / 2642	6%	0.69	39 / 705
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0001525	Biological process	angiogenesis
GO_0001974	Biological process	blood vessel remodeling
GO_0002931	Biological process	response to ischemia
GO_0007165	Biological process	signal transduction
GO_0008217	Biological process	regulation of blood pressure
GO_0033688	Biological process	regulation of osteoblast proliferation
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0002158	Biological process	osteoclast proliferation
GO_0001501	Biological process	skeletal system development
GO_0051000	Biological process	positive regulation of nitric-oxide synthase activity
GO_0035810	Biological process	positive regulation of urine volume
GO_0120163	Biological process	negative regulation of cold-induced thermogenesis
GO_0005886	Cellular component	plasma membrane
GO_0070062	Cellular component	extracellular exosome
GO_0032991	Cellular component	protein-containing complex
GO_0042803	Molecular function	protein homodimerization activity
GO_0031404	Molecular function	chloride ion binding
GO_0042277	Molecular function	peptide binding
GO_0042562	Molecular function	hormone binding
GO_0017046	Molecular function	peptide hormone binding
GO_0008528	Molecular function	G protein-coupled peptide receptor activity
GO_0016941	Molecular function	natriuretic peptide receptor activity
GO_0005515	Molecular function	protein binding

Gene name	NPR3
Protein name	Natriuretic peptide receptor C Atrial natriuretic peptide receptor 3 (Atrial natriuretic peptide clearance receptor) (Atrial natriuretic peptide receptor type C) (ANP-C) (ANPR-C) (NPR-C) Natriuretic peptide receptor 3
Synonyms	C5orf23 hCG_37223 NPRC ANPRC
Description	FUNCTION: Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. .
Accessions	ENST00000265074.13 [P17342-1] ENST00000434067.6 C9JK69 H0Y9B9 P17342 ENST00000509104.5 D6RDL8 ENST00000507141.1 Q60I31 ENST00000326958.5 [P17342-3] ENST00000415167.2 [P17342-2]

NPR3 report