GNA12 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032434Biological processregulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0007188Biological processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO_0001701Biological processin utero embryonic development
GO_1904706Biological processnegative regulation of vascular associated smooth muscle cell proliferation
GO_0008217Biological processregulation of blood pressure
GO_0042733Biological processembryonic digit morphogenesis
GO_0007596Biological processblood coagulation
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0030154Biological processcell differentiation
GO_0007266Biological processRho protein signal transduction
GO_0010762Biological processregulation of fibroblast migration
GO_0008360Biological processregulation of cell shape
GO_1904753Biological processnegative regulation of vascular associated smooth muscle cell migration
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0032516Biological processpositive regulation of phosphoprotein phosphatase activity
GO_0032006Biological processregulation of TOR signaling
GO_0031526Cellular componentbrush border membrane
GO_0005886Cellular componentplasma membrane
GO_0043025Cellular componentneuronal cell body
GO_0043005Cellular componentneuron projection
GO_0005925Cellular componentfocal adhesion
GO_0016328Cellular componentlateral plasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005834Cellular componentheterotrimeric G-protein complex
GO_0031683Molecular functionG-protein beta/gamma-subunit complex binding
GO_0051721Molecular functionprotein phosphatase 2A binding
GO_0031752Molecular functionD5 dopamine receptor binding
GO_0003925Molecular functionG protein activity
GO_0005525Molecular functionGTP binding
GO_0046872Molecular functionmetal ion binding
GO_0019888Molecular functionprotein phosphatase regulator activity
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameGNA12
Protein nameG protein subunit alpha 12
Guanine nucleotide-binding protein subunit alpha-12 (G alpha-12) (G-protein subunit alpha-12)
Synonyms
DescriptionFUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems . Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) . GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins . Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating pro-inflammatory cytokine production . Inhibits CDH1-mediated cell adhesion in process independent from Rho activation . Together with NAPA promotes CDH5 localization to plasma membrane . May play a role in the control of cell migration through the TOR signaling cascade . .

AccessionsE9PC54
Q03113
ENST00000407904.7 [Q03113-2]
ENST00000407653.1
C9J2Y7
ENST00000275364.8 [Q03113-1]
ENST00000447791.1