Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 14 studies | 33% ± 13% | |
oligodendrocyte precursor cell | 12 studies | 38% ± 19% | |
macrophage | 12 studies | 28% ± 13% | |
endothelial cell | 11 studies | 26% ± 13% | |
fibroblast | 10 studies | 28% ± 16% | |
B cell | 8 studies | 28% ± 15% | |
microglial cell | 7 studies | 23% ± 6% | |
dendritic cell | 7 studies | 34% ± 15% | |
GABAergic neuron | 6 studies | 35% ± 17% | |
endothelial cell of lymphatic vessel | 6 studies | 34% ± 19% | |
interneuron | 5 studies | 32% ± 20% | |
neuron | 5 studies | 34% ± 19% | |
myeloid cell | 5 studies | 22% ± 3% | |
adipocyte | 5 studies | 24% ± 5% | |
smooth muscle cell | 5 studies | 35% ± 28% | |
monocyte | 4 studies | 30% ± 16% | |
pericyte | 4 studies | 36% ± 22% | |
glutamatergic neuron | 4 studies | 46% ± 17% | |
oligodendrocyte | 4 studies | 24% ± 4% | |
classical monocyte | 3 studies | 20% ± 3% | |
conventional dendritic cell | 3 studies | 43% ± 22% | |
granule cell | 3 studies | 19% ± 2% | |
epithelial cell | 3 studies | 20% ± 5% | |
alveolar macrophage | 3 studies | 34% ± 13% | |
plasmacytoid dendritic cell | 3 studies | 17% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
stomach | 100% | 3286.72 | 359 / 359 | 100% | 37.52 | 286 / 286 |
brain | 100% | 7219.08 | 2641 / 2642 | 100% | 134.49 | 705 / 705 |
breast | 100% | 4895.43 | 459 / 459 | 100% | 51.49 | 1113 / 1118 |
lung | 100% | 5194.25 | 577 / 578 | 100% | 51.28 | 1151 / 1155 |
intestine | 100% | 5392.04 | 966 / 966 | 99% | 33.95 | 522 / 527 |
prostate | 100% | 4372.99 | 244 / 245 | 99% | 43.97 | 499 / 502 |
uterus | 100% | 6400.55 | 170 / 170 | 98% | 38.18 | 448 / 459 |
adrenal gland | 100% | 5475.69 | 258 / 258 | 97% | 38.32 | 224 / 230 |
thymus | 100% | 2983.31 | 651 / 653 | 97% | 24.26 | 588 / 605 |
skin | 97% | 3674.18 | 1761 / 1809 | 99% | 55.08 | 469 / 472 |
kidney | 100% | 2967.75 | 89 / 89 | 97% | 31.57 | 871 / 901 |
bladder | 100% | 6698.67 | 21 / 21 | 96% | 40.34 | 484 / 504 |
ovary | 100% | 7640.53 | 180 / 180 | 96% | 28.38 | 412 / 430 |
esophagus | 96% | 3937.22 | 1387 / 1445 | 99% | 55.10 | 181 / 183 |
pancreas | 94% | 2014.74 | 307 / 328 | 98% | 42.65 | 175 / 178 |
liver | 85% | 1672.32 | 192 / 226 | 84% | 19.27 | 342 / 406 |
adipose | 100% | 5975.80 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 6688.08 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 66.94 | 29 / 29 |
spleen | 100% | 4406.89 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 38.26 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 12.63 | 1 / 1 |
heart | 100% | 4159.27 | 857 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 98% | 32.13 | 78 / 80 |
peripheral blood | 94% | 2212.28 | 869 / 929 | 0% | 0 | 0 / 0 |
muscle | 92% | 1471.63 | 736 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0032434 | Biological process | regulation of proteasomal ubiquitin-dependent protein catabolic process |
GO_0007188 | Biological process | adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
GO_0001701 | Biological process | in utero embryonic development |
GO_1904706 | Biological process | negative regulation of vascular associated smooth muscle cell proliferation |
GO_0008217 | Biological process | regulation of blood pressure |
GO_0042733 | Biological process | embryonic digit morphogenesis |
GO_0007596 | Biological process | blood coagulation |
GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
GO_0030154 | Biological process | cell differentiation |
GO_0007266 | Biological process | Rho protein signal transduction |
GO_0010762 | Biological process | regulation of fibroblast migration |
GO_0008360 | Biological process | regulation of cell shape |
GO_1904753 | Biological process | negative regulation of vascular associated smooth muscle cell migration |
GO_0009410 | Biological process | response to xenobiotic stimulus |
GO_0032516 | Biological process | positive regulation of phosphoprotein phosphatase activity |
GO_0032006 | Biological process | regulation of TOR signaling |
GO_0031526 | Cellular component | brush border membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0043025 | Cellular component | neuronal cell body |
GO_0043005 | Cellular component | neuron projection |
GO_0005925 | Cellular component | focal adhesion |
GO_0016328 | Cellular component | lateral plasma membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0005834 | Cellular component | heterotrimeric G-protein complex |
GO_0031683 | Molecular function | G-protein beta/gamma-subunit complex binding |
GO_0051721 | Molecular function | protein phosphatase 2A binding |
GO_0031752 | Molecular function | D5 dopamine receptor binding |
GO_0003925 | Molecular function | G protein activity |
GO_0005525 | Molecular function | GTP binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0019888 | Molecular function | protein phosphatase regulator activity |
GO_0005515 | Molecular function | protein binding |
GO_0003924 | Molecular function | GTPase activity |
Gene name | GNA12 |
Protein name | G protein subunit alpha 12 Guanine nucleotide-binding protein subunit alpha-12 (G alpha-12) (G-protein subunit alpha-12) |
Synonyms | |
Description | FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems . Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) . GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins . Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating pro-inflammatory cytokine production . Inhibits CDH1-mediated cell adhesion in process independent from Rho activation . Together with NAPA promotes CDH5 localization to plasma membrane . May play a role in the control of cell migration through the TOR signaling cascade . . |
Accessions | E9PC54 Q03113 ENST00000407904.7 [Q03113-2] ENST00000407653.1 C9J2Y7 ENST00000275364.8 [Q03113-1] ENST00000447791.1 |