I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 8 studies | 40% ± 19% | |
| pancreatic A cell | 4 studies | 54% ± 27% | |
| GABAergic neuron | 4 studies | 28% ± 8% | |
| neuron | 3 studies | 35% ± 10% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 8 studies | 40% ± 19% | |
| pancreatic A cell | 4 studies | 54% ± 27% | |
| GABAergic neuron | 4 studies | 28% ± 8% | |
| neuron | 3 studies | 35% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 81% | 7162.09 | 2140 / 2642 | 82% | 32.15 | 581 / 705 |
| adrenal gland | 59% | 678.15 | 153 / 258 | 80% | 173.10 | 184 / 230 |
| esophagus | 55% | 883.74 | 790 / 1445 | 52% | 4.71 | 95 / 183 |
| pancreas | 13% | 65.23 | 44 / 328 | 88% | 13.23 | 156 / 178 |
| uterus | 21% | 117.11 | 36 / 170 | 73% | 8.60 | 335 / 459 |
| thymus | 44% | 312.20 | 289 / 653 | 49% | 7.85 | 299 / 605 |
| ovary | 26% | 174.33 | 47 / 180 | 67% | 6.00 | 288 / 430 |
| breast | 6% | 31.85 | 29 / 459 | 86% | 10.69 | 956 / 1118 |
| prostate | 43% | 251.56 | 105 / 245 | 49% | 2.36 | 244 / 502 |
| stomach | 45% | 874.69 | 163 / 359 | 42% | 4.02 | 121 / 286 |
| intestine | 49% | 366.39 | 476 / 966 | 32% | 3.12 | 171 / 527 |
| blood vessel | 74% | 1410.79 | 983 / 1335 | 0% | 0 | 0 / 0 |
| lung | 13% | 72.44 | 76 / 578 | 60% | 4.54 | 692 / 1155 |
| kidney | 18% | 99.45 | 16 / 89 | 53% | 4.07 | 475 / 901 |
| bladder | 24% | 91.43 | 5 / 21 | 40% | 3.35 | 202 / 504 |
| skin | 17% | 244.56 | 308 / 1809 | 37% | 5.55 | 175 / 472 |
| tonsil | 0% | 0 | 0 / 0 | 53% | 4.70 | 24 / 45 |
| heart | 36% | 256.18 | 313 / 861 | 0% | 0 | 0 / 0 |
| liver | 8% | 36.11 | 18 / 226 | 25% | 9.10 | 102 / 406 |
| adipose | 33% | 442.78 | 396 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 23% | 2.65 | 18 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 21% | 1.29 | 6 / 29 |
| spleen | 17% | 84.53 | 41 / 241 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0.55 | 1 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0.40 | 1 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0060160 | Biological process | negative regulation of dopamine receptor signaling pathway |
| GO_0110053 | Biological process | regulation of actin filament organization |
| GO_0051924 | Biological process | regulation of calcium ion transport |
| GO_1901380 | Biological process | negative regulation of potassium ion transmembrane transport |
| GO_0045471 | Biological process | response to ethanol |
| GO_0045744 | Biological process | negative regulation of G protein-coupled receptor signaling pathway |
| GO_2000463 | Biological process | positive regulation of excitatory postsynaptic potential |
| GO_0061052 | Biological process | negative regulation of cell growth involved in cardiac muscle cell development |
| GO_0042220 | Biological process | response to cocaine |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0008277 | Biological process | regulation of G protein-coupled receptor signaling pathway |
| GO_1990791 | Biological process | dorsal root ganglion development |
| GO_0001975 | Biological process | response to amphetamine |
| GO_1900924 | Biological process | negative regulation of glycine import across plasma membrane |
| GO_0010460 | Biological process | positive regulation of heart rate |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0032991 | Cellular component | protein-containing complex |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0001965 | Molecular function | G-protein alpha-subunit binding |
| GO_0019901 | Molecular function | protein kinase binding |
| GO_0005096 | Molecular function | GTPase activator activity |
| GO_0005516 | Molecular function | calmodulin binding |
| GO_0003924 | Molecular function | GTPase activity |
| Gene name | RGS4 |
| Protein name | Regulator of G protein signaling 4 Regulator of G-protein signaling 4 (RGP4) (RGS4) |
| Synonyms | |
| Description | FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. |
| Accessions | E9PS05 ENST00000528938.1 P49798 E9PR32 ENST00000367909.11 [P49798-1] ENST00000527809.5 [P49798-5] ENST00000367906.7 [P49798-5] ENST00000421743.6 [P49798-3] ENST00000367908.8 [P49798-4] ENST00000531057.5 |
