UCN report

I. Expression across cell types

Insufficient scRNA-seq data for expression of UCN at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of UCN at tissue level.

III. Associated gene sets

GO_0032099Biological processnegative regulation of appetite
GO_0046888Biological processnegative regulation of hormone secretion
GO_0042756Biological processdrinking behavior
GO_0032355Biological processresponse to estradiol
GO_0007605Biological processsensory perception of sound
GO_0010996Biological processresponse to auditory stimulus
GO_0007218Biological processneuropeptide signaling pathway
GO_0030307Biological processpositive regulation of cell growth
GO_0010629Biological processnegative regulation of gene expression
GO_0031175Biological processneuron projection development
GO_0033138Biological processpositive regulation of peptidyl-serine phosphorylation
GO_0008306Biological processassociative learning
GO_2000987Biological processpositive regulation of behavioral fear response
GO_0060452Biological processpositive regulation of cardiac muscle contraction
GO_0051966Biological processregulation of synaptic transmission, glutamatergic
GO_0007565Biological processfemale pregnancy
GO_0090280Biological processpositive regulation of calcium ion import
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0051384Biological processresponse to glucocorticoid
GO_0045776Biological processnegative regulation of blood pressure
GO_0032967Biological processpositive regulation of collagen biosynthetic process
GO_0048265Biological processresponse to pain
GO_0045740Biological processpositive regulation of DNA replication
GO_0043950Biological processpositive regulation of cAMP-mediated signaling
GO_0045727Biological processpositive regulation of translation
GO_0001964Biological processstartle response
GO_2000252Biological processnegative regulation of feeding behavior
GO_0051461Biological processpositive regulation of corticotropin secretion
GO_0009060Biological processaerobic respiration
GO_0042311Biological processvasodilation
GO_0035176Biological processsocial behavior
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0006979Biological processresponse to oxidative stress
GO_0045792Biological processnegative regulation of cell size
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0043117Biological processpositive regulation of vascular permeability
GO_0005576Cellular componentextracellular region
GO_0043204Cellular componentperikaryon
GO_0043679Cellular componentaxon terminus
GO_0030425Cellular componentdendrite
GO_0043196Cellular componentvaricosity
GO_0046811Molecular functionhistone deacetylase inhibitor activity
GO_0051430Molecular functioncorticotropin-releasing hormone receptor 1 binding
GO_0051431Molecular functioncorticotropin-releasing hormone receptor 2 binding
GO_0005515Molecular functionprotein binding
GO_0005184Molecular functionneuropeptide hormone activity

IV. Literature review

[source]
Gene nameUCN
Protein nameUrocortin
Synonyms
DescriptionFUNCTION: Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) . Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta . Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity). .

AccessionsENST00000296099.2
P55089