Insufficient scRNA-seq data for expression of UCN at single-cell level.
Insufficient scRNA-seq data for expression of UCN at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 217.35 | 2642 / 2642 | 99% | 15.74 | 700 / 705 |
prostate | 100% | 118.56 | 244 / 245 | 92% | 6.95 | 464 / 502 |
adrenal gland | 100% | 156.52 | 258 / 258 | 87% | 12.52 | 200 / 230 |
thymus | 94% | 67.38 | 617 / 653 | 92% | 7.91 | 559 / 605 |
uterus | 98% | 114.33 | 167 / 170 | 76% | 5.25 | 347 / 459 |
breast | 94% | 61.24 | 431 / 459 | 71% | 4.63 | 798 / 1118 |
kidney | 92% | 63.94 | 82 / 89 | 70% | 4.79 | 635 / 901 |
liver | 97% | 113.43 | 219 / 226 | 66% | 3.78 | 266 / 406 |
skin | 88% | 42.17 | 1584 / 1809 | 73% | 5.08 | 344 / 472 |
bladder | 100% | 103.24 | 21 / 21 | 56% | 3.06 | 281 / 504 |
intestine | 95% | 72.42 | 920 / 966 | 57% | 2.80 | 299 / 527 |
pancreas | 78% | 44.88 | 256 / 328 | 71% | 3.51 | 127 / 178 |
lung | 95% | 73.72 | 548 / 578 | 53% | 2.91 | 610 / 1155 |
esophagus | 84% | 64.61 | 1213 / 1445 | 55% | 2.26 | 100 / 183 |
ovary | 98% | 101.33 | 177 / 180 | 40% | 1.85 | 173 / 430 |
stomach | 74% | 36.71 | 265 / 359 | 51% | 2.16 | 146 / 286 |
muscle | 100% | 126.90 | 800 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 107.47 | 240 / 241 | 0% | 0 | 0 / 0 |
heart | 98% | 92.39 | 845 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 97% | 6.25 | 28 / 29 |
adipose | 90% | 49.02 | 1086 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 89% | 49.46 | 1184 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 65% | 28.47 | 605 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 55% | 2.01 | 44 / 80 |
tonsil | 0% | 0 | 0 / 0 | 44% | 1.83 | 20 / 45 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0032099 | Biological process | negative regulation of appetite |
GO_0046888 | Biological process | negative regulation of hormone secretion |
GO_0042756 | Biological process | drinking behavior |
GO_0032355 | Biological process | response to estradiol |
GO_0007605 | Biological process | sensory perception of sound |
GO_0010996 | Biological process | response to auditory stimulus |
GO_0007218 | Biological process | neuropeptide signaling pathway |
GO_0030307 | Biological process | positive regulation of cell growth |
GO_0010629 | Biological process | negative regulation of gene expression |
GO_0031175 | Biological process | neuron projection development |
GO_0033138 | Biological process | positive regulation of peptidyl-serine phosphorylation |
GO_0008306 | Biological process | associative learning |
GO_2000987 | Biological process | positive regulation of behavioral fear response |
GO_0060452 | Biological process | positive regulation of cardiac muscle contraction |
GO_0051966 | Biological process | regulation of synaptic transmission, glutamatergic |
GO_0007565 | Biological process | female pregnancy |
GO_0090280 | Biological process | positive regulation of calcium ion import |
GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
GO_0051384 | Biological process | response to glucocorticoid |
GO_0045776 | Biological process | negative regulation of blood pressure |
GO_0032967 | Biological process | positive regulation of collagen biosynthetic process |
GO_0048265 | Biological process | response to pain |
GO_0045740 | Biological process | positive regulation of DNA replication |
GO_0043950 | Biological process | positive regulation of cAMP-mediated signaling |
GO_0045727 | Biological process | positive regulation of translation |
GO_0001964 | Biological process | startle response |
GO_2000252 | Biological process | negative regulation of feeding behavior |
GO_0051461 | Biological process | positive regulation of corticotropin secretion |
GO_0009060 | Biological process | aerobic respiration |
GO_0042311 | Biological process | vasodilation |
GO_0035176 | Biological process | social behavior |
GO_0043524 | Biological process | negative regulation of neuron apoptotic process |
GO_0006979 | Biological process | response to oxidative stress |
GO_0045792 | Biological process | negative regulation of cell size |
GO_0032755 | Biological process | positive regulation of interleukin-6 production |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0043117 | Biological process | positive regulation of vascular permeability |
GO_0005576 | Cellular component | extracellular region |
GO_0043204 | Cellular component | perikaryon |
GO_0043679 | Cellular component | axon terminus |
GO_0030425 | Cellular component | dendrite |
GO_0043196 | Cellular component | varicosity |
GO_0046811 | Molecular function | histone deacetylase inhibitor activity |
GO_0051430 | Molecular function | corticotropin-releasing hormone receptor 1 binding |
GO_0051431 | Molecular function | corticotropin-releasing hormone receptor 2 binding |
GO_0005515 | Molecular function | protein binding |
GO_0005184 | Molecular function | neuropeptide hormone activity |
Gene name | UCN |
Protein name | Urocortin |
Synonyms | |
Description | FUNCTION: Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) . Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta . Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity). . |
Accessions | ENST00000296099.2 P55089 |