RGS14 report

II. Expression across tissues

III. Associated gene sets

GO_0000278Biological processmitotic cell cycle
GO_0007059Biological processchromosome segregation
GO_0007612Biological processlearning
GO_0007616Biological processlong-term memory
GO_0070373Biological processnegative regulation of ERK1 and ERK2 cascade
GO_0050769Biological processpositive regulation of neurogenesis
GO_0051301Biological processcell division
GO_0060291Biological processlong-term synaptic potentiation
GO_0045744Biological processnegative regulation of G protein-coupled receptor signaling pathway
GO_0031914Biological processnegative regulation of synaptic plasticity
GO_0008542Biological processvisual learning
GO_0010070Biological processzygote asymmetric cell division
GO_0048008Biological processplatelet-derived growth factor receptor signaling pathway
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0008277Biological processregulation of G protein-coupled receptor signaling pathway
GO_0006913Biological processnucleocytoplasmic transport
GO_0043407Biological processnegative regulation of MAP kinase activity
GO_0006979Biological processresponse to oxidative stress
GO_0007051Biological processspindle organization
GO_0098978Cellular componentglutamatergic synapse
GO_0005886Cellular componentplasma membrane
GO_0005874Cellular componentmicrotubule
GO_0000922Cellular componentspindle pole
GO_0043197Cellular componentdendritic spine
GO_0005813Cellular componentcentrosome
GO_0030425Cellular componentdendrite
GO_0016604Cellular componentnuclear body
GO_0014069Cellular componentpostsynaptic density
GO_0016605Cellular componentPML body
GO_0005737Cellular componentcytoplasm
GO_0005819Cellular componentspindle
GO_0005634Cellular componentnucleus
GO_0005092Molecular functionGDP-dissociation inhibitor activity
GO_0032794Molecular functionGTPase activating protein binding
GO_0001965Molecular functionG-protein alpha-subunit binding
GO_0019901Molecular functionprotein kinase binding
GO_0005096Molecular functionGTPase activator activity
GO_0030159Molecular functionsignaling receptor complex adaptor activity
GO_0008017Molecular functionmicrotubule binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRGS14
Protein nameRegulator of G-protein signaling 14 (RGS14)
Regulator of G protein signaling 14
Synonyms
DescriptionFUNCTION: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o)-alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory. .

AccessionsO43566
ENST00000408923.8 [O43566-7]
ENST00000511890.1
H0Y8W3