Name | Number of supported studies | Average coverage | |
---|---|---|---|
CD4-positive, alpha-beta T cell | 10 studies | 21% ± 4% | |
regulatory T cell | 8 studies | 18% ± 2% | |
mucosal invariant T cell | 7 studies | 20% ± 3% | |
gamma-delta T cell | 7 studies | 19% ± 6% | |
CD8-positive, alpha-beta T cell | 6 studies | 23% ± 8% | |
classical monocyte | 6 studies | 24% ± 8% | |
naive thymus-derived CD8-positive, alpha-beta T cell | 6 studies | 18% ± 3% | |
T cell | 5 studies | 19% ± 2% | |
effector memory CD8-positive, alpha-beta T cell | 5 studies | 19% ± 3% | |
naive thymus-derived CD4-positive, alpha-beta T cell | 5 studies | 18% ± 2% | |
CD8-positive, alpha-beta memory T cell | 4 studies | 20% ± 2% | |
conventional dendritic cell | 3 studies | 32% ± 11% | |
non-classical monocyte | 3 studies | 19% ± 1% | |
CD16-negative, CD56-bright natural killer cell, human | 3 studies | 25% ± 7% | |
ciliated cell | 3 studies | 18% ± 2% | |
dendritic cell | 3 studies | 26% ± 2% | |
effector memory CD4-positive, alpha-beta T cell | 3 studies | 21% ± 2% | |
T follicular helper cell | 3 studies | 18% ± 2% | |
CD4-positive, alpha-beta memory T cell | 3 studies | 20% ± 6% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
peripheral blood | 5 studies | 16% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
liver | 100% | 2953.71 | 226 / 226 | 99% | 43.32 | 403 / 406 |
kidney | 100% | 2151.96 | 89 / 89 | 99% | 39.47 | 891 / 901 |
thymus | 99% | 1484.28 | 649 / 653 | 99% | 26.10 | 601 / 605 |
lung | 96% | 1145.38 | 557 / 578 | 97% | 19.91 | 1124 / 1155 |
prostate | 96% | 1077.25 | 234 / 245 | 97% | 14.04 | 489 / 502 |
pancreas | 87% | 759.30 | 286 / 328 | 98% | 22.08 | 174 / 178 |
intestine | 87% | 988.49 | 838 / 966 | 97% | 17.33 | 513 / 527 |
stomach | 87% | 663.86 | 312 / 359 | 97% | 14.69 | 276 / 286 |
bladder | 86% | 763.24 | 18 / 21 | 94% | 17.26 | 474 / 504 |
esophagus | 84% | 1384.40 | 1208 / 1445 | 95% | 15.74 | 173 / 183 |
uterus | 76% | 655.84 | 130 / 170 | 100% | 30.69 | 458 / 459 |
skin | 72% | 1166.18 | 1305 / 1809 | 97% | 21.31 | 459 / 472 |
breast | 69% | 566.78 | 316 / 459 | 94% | 19.00 | 1052 / 1118 |
adrenal gland | 85% | 681.62 | 220 / 258 | 48% | 6.49 | 110 / 230 |
ovary | 26% | 142.33 | 46 / 180 | 99% | 19.91 | 426 / 430 |
brain | 71% | 6966.22 | 1865 / 2642 | 42% | 4.84 | 297 / 705 |
lymph node | 0% | 0 | 0 / 0 | 100% | 39.87 | 29 / 29 |
peripheral blood | 100% | 9412.71 | 929 / 929 | 0% | 0 | 0 / 0 |
spleen | 100% | 5323.73 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 40.59 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 8.17 | 1 / 1 |
eye | 0% | 0 | 0 / 0 | 94% | 13.19 | 75 / 80 |
adipose | 67% | 475.78 | 803 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 32% | 220.79 | 427 / 1335 | 0% | 0 | 0 / 0 |
muscle | 19% | 126.15 | 152 / 803 | 0% | 0 | 0 / 0 |
heart | 9% | 50.63 | 77 / 861 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0000278 | Biological process | mitotic cell cycle |
GO_0007059 | Biological process | chromosome segregation |
GO_0007612 | Biological process | learning |
GO_0007616 | Biological process | long-term memory |
GO_0070373 | Biological process | negative regulation of ERK1 and ERK2 cascade |
GO_0050769 | Biological process | positive regulation of neurogenesis |
GO_0051301 | Biological process | cell division |
GO_0060291 | Biological process | long-term synaptic potentiation |
GO_0045744 | Biological process | negative regulation of G protein-coupled receptor signaling pathway |
GO_0031914 | Biological process | negative regulation of synaptic plasticity |
GO_0008542 | Biological process | visual learning |
GO_0010070 | Biological process | zygote asymmetric cell division |
GO_0048008 | Biological process | platelet-derived growth factor receptor signaling pathway |
GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
GO_0008277 | Biological process | regulation of G protein-coupled receptor signaling pathway |
GO_0006913 | Biological process | nucleocytoplasmic transport |
GO_0043407 | Biological process | negative regulation of MAP kinase activity |
GO_0006979 | Biological process | response to oxidative stress |
GO_0007051 | Biological process | spindle organization |
GO_0098978 | Cellular component | glutamatergic synapse |
GO_0005886 | Cellular component | plasma membrane |
GO_0005874 | Cellular component | microtubule |
GO_0000922 | Cellular component | spindle pole |
GO_0043197 | Cellular component | dendritic spine |
GO_0005813 | Cellular component | centrosome |
GO_0030425 | Cellular component | dendrite |
GO_0016604 | Cellular component | nuclear body |
GO_0014069 | Cellular component | postsynaptic density |
GO_0016605 | Cellular component | PML body |
GO_0005737 | Cellular component | cytoplasm |
GO_0005819 | Cellular component | spindle |
GO_0005634 | Cellular component | nucleus |
GO_0005092 | Molecular function | GDP-dissociation inhibitor activity |
GO_0032794 | Molecular function | GTPase activating protein binding |
GO_0001965 | Molecular function | G-protein alpha-subunit binding |
GO_0019901 | Molecular function | protein kinase binding |
GO_0005096 | Molecular function | GTPase activator activity |
GO_0030159 | Molecular function | signaling receptor complex adaptor activity |
GO_0008017 | Molecular function | microtubule binding |
GO_0005515 | Molecular function | protein binding |
GO_0003924 | Molecular function | GTPase activity |
Gene name | RGS14 |
Protein name | Regulator of G-protein signaling 14 (RGS14) Regulator of G protein signaling 14 |
Synonyms | |
Description | FUNCTION: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o)-alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory. . |
Accessions | O43566 ENST00000408923.8 [O43566-7] ENST00000511890.1 H0Y8W3 |