RGS1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	34 studies	48% ± 21%	Explore
mast cell	29 studies	53% ± 25%	Explore
CD8-positive, alpha-beta T cell	29 studies	45% ± 19%	Explore
T cell	27 studies	40% ± 16%	Explore
CD4-positive, alpha-beta T cell	27 studies	37% ± 14%	Explore
dendritic cell	26 studies	55% ± 25%	Explore
regulatory T cell	26 studies	53% ± 20%	Explore
conventional dendritic cell	25 studies	52% ± 16%	Explore
natural killer cell	24 studies	39% ± 19%	Explore
B cell	19 studies	30% ± 12%	Explore
plasmacytoid dendritic cell	18 studies	50% ± 21%	Explore
plasma cell	16 studies	40% ± 13%	Explore
microglial cell	15 studies	42% ± 22%	Explore
mature NK T cell	13 studies	41% ± 17%	Explore
gamma-delta T cell	12 studies	46% ± 25%	Explore
myeloid cell	11 studies	45% ± 24%	Explore
memory B cell	10 studies	36% ± 18%	Explore
leukocyte	9 studies	46% ± 21%	Explore
innate lymphoid cell	8 studies	38% ± 18%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	42% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	46% ± 19%	Explore
mononuclear phagocyte	7 studies	46% ± 20%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	28% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	34% ± 15%	Explore
IgA plasma cell	7 studies	38% ± 18%	Explore
IgG plasma cell	7 studies	46% ± 20%	Explore
T follicular helper cell	7 studies	37% ± 19%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	38% ± 18%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	26% ± 11%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	6 studies	20% ± 4%	Explore
monocyte	6 studies	40% ± 11%	Explore
naive B cell	6 studies	30% ± 14%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	40% ± 25%	Explore
mucosal invariant T cell	5 studies	26% ± 9%	Explore
group 3 innate lymphoid cell	5 studies	71% ± 16%	Explore
CD4-positive helper T cell	5 studies	46% ± 9%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	41% ± 16%	Explore
monocyte-derived dendritic cell	4 studies	66% ± 8%	Explore
T-helper 17 cell	4 studies	75% ± 9%	Explore
germinal center B cell	4 studies	38% ± 11%	Explore
Langerhans cell	3 studies	64% ± 27%	Explore
classical monocyte	3 studies	25% ± 7%	Explore
exhausted T cell	3 studies	51% ± 8%	Explore
tissue-resident macrophage	3 studies	59% ± 30%	Explore
intraepithelial lymphocyte	3 studies	47% ± 20%	Explore
plasmablast	3 studies	44% ± 14%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	36% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
intestine	7 studies	39% ± 24%	Explore
lung	5 studies	29% ± 8%	Explore
lymph node	5 studies	44% ± 13%	Explore
peripheral blood	3 studies	20% ± 3%	Explore
kidney	3 studies	37% ± 12%	Explore
liver	3 studies	32% ± 13%	Explore
thymus	3 studies	17% ± 1%	Explore
brain	3 studies	35% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	98%	5756.39	568 / 578	91%	73.02	1046 / 1155
prostate	98%	3954.89	239 / 245	84%	38.87	420 / 502
intestine	97%	4235.32	934 / 966	67%	29.88	354 / 527
bladder	95%	3964.43	20 / 21	68%	35.74	342 / 504
breast	71%	2379.05	324 / 459	84%	54.72	937 / 1118
kidney	48%	1171.70	43 / 89	87%	81.79	788 / 901
esophagus	59%	1041.28	852 / 1445	74%	39.10	136 / 183
thymus	63%	1808.55	411 / 653	68%	35.16	411 / 605
uterus	55%	984.09	94 / 170	69%	38.81	319 / 459
stomach	49%	863.27	177 / 359	72%	45.84	206 / 286
brain	39%	2500.32	1033 / 2642	79%	67.92	557 / 705
skin	44%	740.36	795 / 1809	73%	98.74	343 / 472
ovary	44%	580.53	79 / 180	73%	36.70	312 / 430
pancreas	25%	405.98	81 / 328	89%	67.22	159 / 178
adrenal gland	55%	1601.57	142 / 258	53%	22.94	121 / 230
lymph node	0%	0	0 / 0	97%	110.10	28 / 29
spleen	94%	5298.73	227 / 241	0%	0	0 / 0
blood vessel	90%	3922.87	1198 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	78%	49.65	35 / 45
adipose	74%	2093.95	889 / 1204	0%	0	0 / 0
liver	36%	625.83	82 / 226	36%	15.71	146 / 406
peripheral blood	52%	6634.11	487 / 929	0%	0	0 / 0
heart	38%	817.52	326 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	15%	6.75	12 / 80
muscle	1%	22.75	12 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007165	Biological process	signal transduction
GO_0006955	Biological process	immune response
GO_0061737	Biological process	leukotriene signaling pathway
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0007193	Biological process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO_0043547	Biological process	positive regulation of GTPase activity
GO_0009968	Biological process	negative regulation of signal transduction
GO_0009617	Biological process	response to bacterium
GO_0009898	Cellular component	cytoplasmic side of plasma membrane
GO_0005829	Cellular component	cytosol
GO_0005886	Cellular component	plasma membrane
GO_0003924	Molecular function	GTPase activity
GO_0005516	Molecular function	calmodulin binding
GO_0001965	Molecular function	G-protein alpha-subunit binding
GO_0005096	Molecular function	GTPase activator activity

IV. Literature review

[source]

Gene name	RGS1
Protein name	Regulator of G-protein signaling 1 (RGS1) (B-cell activation protein BL34) (Early response protein 1R20)
Synonyms	1R20 IER1 BL34
Description	FUNCTION: Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors . Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form . .
Accessions	ENST00000469578.2 [Q08116-2] Q08116 ENST00000367459.8 [Q08116-1]

RGS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review