GPR31 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GPR31 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GPR31 at tissue level.

III. Associated gene sets

GO_0002237Biological processresponse to molecule of bacterial origin
GO_0050778Biological processpositive regulation of immune response
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0050728Biological processnegative regulation of inflammatory response
GO_0002931Biological processresponse to ischemia
GO_0006629Biological processlipid metabolic process
GO_0010447Biological processresponse to acidic pH
GO_0005886Cellular componentplasma membrane
GO_0050544Molecular functionarachidonic acid binding
GO_0045125Molecular functionbioactive lipid receptor activity
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGPR31
Protein name12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor (12-(S)-HETE receptor) (12-HETER) (G-protein coupled receptor 31) (GPR31/12-HETER)
Synonyms
DescriptionFUNCTION: High-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE), with much lower affinities for other HETE isomers . 12-S-HETE is a eicosanoid, a 12-lipoxygenase (ALOX12) metabolite of arachidonic acid, involved in many physiologic and pathologic processes . 12-S-HETE-binding leads to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B pathways leading to cell growth . Plays a crucial role for proliferation, survival and macropinocytosis of KRAS-dependent cancer cells by mediating the translocation of KRAS from the endoplasmic reticulum to the plasma membrane (PM) and its association with the PM . Contributes to enhanced immune responses by inducing dendrite protrusion of small intestinal CX3CR1(+) phagocytes for the uptake of luminal antigens (By similarity). Acts also as a key receptor for 12-(S)-HETE-mediated liver ischemia reperfusion injury . .; FUNCTION: Proton-sensing G protein-coupled receptor. .

AccessionsO00270
ENST00000366834.2