GPR15LG report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043303Biological processmast cell degranulation
GO_0043029Biological processT cell homeostasis
GO_0051782Biological processnegative regulation of cell division
GO_0050832Biological processdefense response to fungus
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0048247Biological processlymphocyte chemotaxis
GO_0010837Biological processregulation of keratinocyte proliferation
GO_1902807Biological processnegative regulation of cell cycle G1/S phase transition
GO_2000404Biological processregulation of T cell migration
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005515Molecular functionprotein binding
GO_0008009Molecular functionchemokine activity
GO_0048018Molecular functionreceptor ligand activity
GO_0001664Molecular functionG protein-coupled receptor binding

IV. Literature review

[source]
Gene nameGPR15LG
Protein nameProtein GPR15LG (Antimicrobial peptide with 57 amino acid residues) (AP-57) (Antimicrobial peptide-57) (Colon-derived SUSD2 binding factor) (CSBF) (Protein GPR15 ligand) (Protein GPR15L) (Secreted protein C10orf99)
SynonymsC10orf99
GPR15L
UNQ1833/PRO3446
DescriptionFUNCTION: Highly cationic protein that has multiple functions. Acts as a chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G-protein coupled receptor GPR15 . May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest . May regulate keratinocyte proliferation . In addition, through activation of Mas-related G protein-coupled receptors (MRGPRs) contributes to pruritogenesis by activating itch-selective sensory neurons and mast cells degranulation . .; FUNCTION: Has antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Actinomyces spec., and Mycoplasma hominis and lentivirus . .

AccessionsENST00000372126.4
Q6UWK7