GHSR | OmnibusX

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GHSR at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
pancreas	36%	2.22	118 / 328	6%	0.08	10 / 178
peripheral blood	19%	1.21	174 / 929	0%	0	0 / 0
brain	15%	3.86	404 / 2642	0%	0.00	1 / 705
adrenal gland	13%	1.38	33 / 258	2%	0.20	5 / 230
stomach	11%	0.68	41 / 359	1%	0.01	2 / 286
lung	10%	0.70	58 / 578	0%	0.01	4 / 1155
spleen	8%	0.36	20 / 241	0%	0	0 / 0
intestine	7%	0.33	71 / 966	1%	0.02	4 / 527
esophagus	7%	0.38	99 / 1445	1%	0.01	1 / 183
muscle	5%	0.24	42 / 803	0%	0	0 / 0
liver	4%	0.16	9 / 226	0%	0.01	2 / 406
adipose	2%	0.12	29 / 1204	0%	0	0 / 0
breast	2%	0.07	8 / 459	1%	0.13	6 / 1118
blood vessel	2%	0.08	25 / 1335	0%	0	0 / 0
thymus	2%	0.08	12 / 653	0%	0	0 / 605
uterus	2%	0.06	3 / 170	0%	0	0 / 459
prostate	1%	0.04	3 / 245	0%	0.01	1 / 502
ovary	1%	0.05	2 / 180	0%	0.01	1 / 430
skin	1%	0.07	15 / 1809	0%	0	0 / 472
heart	1%	0.03	6 / 861	0%	0	0 / 0
bladder	0%	0	0 / 21	0%	0.14	2 / 504
kidney	0%	0	0 / 89	0%	0.00	1 / 901
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0032099	Biological process	negative regulation of appetite
GO_0032355	Biological process	response to estradiol
GO_1990314	Biological process	cellular response to insulin-like growth factor stimulus
GO_0007283	Biological process	spermatogenesis
GO_0032869	Biological process	cellular response to insulin stimulus
GO_2000110	Biological process	negative regulation of macrophage apoptotic process
GO_0045923	Biological process	positive regulation of fatty acid metabolic process
GO_0007611	Biological process	learning or memory
GO_0032715	Biological process	negative regulation of interleukin-6 production
GO_0046697	Biological process	decidualization
GO_1905333	Biological process	regulation of gastric motility
GO_0030252	Biological process	growth hormone secretion
GO_1904349	Biological process	positive regulation of small intestine smooth muscle contraction
GO_0048009	Biological process	insulin-like growth factor receptor signaling pathway
GO_0008343	Biological process	adult feeding behavior
GO_0097067	Biological process	cellular response to thyroid hormone stimulus
GO_0120058	Biological process	positive regulation of small intestinal transit
GO_1905564	Biological process	positive regulation of vascular endothelial cell proliferation
GO_1903672	Biological process	positive regulation of sprouting angiogenesis
GO_1904000	Biological process	positive regulation of eating behavior
GO_0046676	Biological process	negative regulation of insulin secretion
GO_0032691	Biological process	negative regulation of interleukin-1 beta production
GO_0008154	Biological process	actin polymerization or depolymerization
GO_0036321	Biological process	ghrelin secretion
GO_0060416	Biological process	response to growth hormone
GO_0071548	Biological process	response to dexamethasone
GO_0009725	Biological process	response to hormone
GO_0090327	Biological process	negative regulation of locomotion involved in locomotory behavior
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0032354	Biological process	response to follicle-stimulating hormone
GO_0050728	Biological process	negative regulation of inflammatory response
GO_0051963	Biological process	regulation of synapse assembly
GO_0043568	Biological process	positive regulation of insulin-like growth factor receptor signaling pathway
GO_0032100	Biological process	positive regulation of appetite
GO_0009755	Biological process	hormone-mediated signaling pathway
GO_0071222	Biological process	cellular response to lipopolysaccharide
GO_0043134	Biological process	regulation of hindgut contraction
GO_0060123	Biological process	regulation of growth hormone secretion
GO_0098696	Biological process	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
GO_0099170	Biological process	postsynaptic modulation of chemical synaptic transmission
GO_0051969	Biological process	regulation of transmission of nerve impulse
GO_0032094	Biological process	response to food
GO_0032720	Biological process	negative regulation of tumor necrosis factor production
GO_1902065	Biological process	response to L-glutamate
GO_0040018	Biological process	positive regulation of multicellular organism growth
GO_0010700	Biological process	negative regulation of norepinephrine secretion
GO_0099175	Biological process	regulation of postsynapse organization
GO_0098978	Cellular component	glutamatergic synapse
GO_0098685	Cellular component	Schaffer collateral - CA1 synapse
GO_0005886	Cellular component	plasma membrane
GO_0045121	Cellular component	membrane raft
GO_0097060	Cellular component	synaptic membrane
GO_0098794	Cellular component	postsynapse
GO_0043005	Cellular component	neuron projection
GO_0009986	Cellular component	cell surface
GO_0004930	Molecular function	G protein-coupled receptor activity
GO_0017046	Molecular function	peptide hormone binding
GO_0001616	Molecular function	growth hormone secretagogue receptor activity
GO_0016520	Molecular function	growth hormone-releasing hormone receptor activity

Gene name	GHSR
Protein name	Growth hormone secretagogue receptor Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor)
Synonyms
Description	FUNCTION: Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine). .
Accessions	ENST00000241256.3 [Q92847-1] Q92847 A2T3X1 ENST00000427970.1 [Q92847-2]

GHSR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review