ARHGEF12 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007266Biological processRho protein signal transduction
GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0005515Molecular functionprotein binding
GO_0005096Molecular functionGTPase activator activity
GO_0001664Molecular functionG protein-coupled receptor binding

IV. Literature review

[source]
Gene nameARHGEF12
Protein nameRho guanine nucleotide exchange factor 12
Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF)
ARHGEF12
SynonymsLARG
KIAA0382
DescriptionFUNCTION: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. .

AccessionsENST00000397843.7 [Q9NZN5-1]
ENST00000532993.5
ENST00000356641.7 [Q9NZN5-2]
Q9NZN5
E9PMR6
A0A2X0SFF5