SSTR4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SSTR4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SSTR4 at tissue level.

III. Associated gene sets

GO_0071385Biological processcellular response to glucocorticoid stimulus
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0038170Biological processsomatostatin signaling pathway
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0007218Biological processneuropeptide signaling pathway
GO_0090238Biological processpositive regulation of arachidonic acid secretion
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0106072Biological processnegative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0016477Biological processcell migration
GO_0030900Biological processforebrain development
GO_0007187Biological processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO_0005886Cellular componentplasma membrane
GO_0043005Cellular componentneuron projection
GO_0042923Molecular functionneuropeptide binding
GO_0004994Molecular functionsomatostatin receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSSTR4
Protein nameSomatostatin receptor type 4 (SS-4-R) (SS4-R) (SS4R) (SST4)
Synonyms
DescriptionFUNCTION: Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.

AccessionsP31391
ENST00000255008.5