OPN3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of OPN3 at tissue level.

III. Associated gene sets

GO_0030216Biological processkeratinocyte differentiation
GO_0046326Biological processpositive regulation of glucose import
GO_0007602Biological processphototransduction
GO_0071482Biological processcellular response to light stimulus
GO_0009583Biological processdetection of light stimulus
GO_0042752Biological processregulation of circadian rhythm
GO_0048022Biological processnegative regulation of melanin biosynthetic process
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0043066Biological processnegative regulation of apoptotic process
GO_0009584Biological processdetection of visible light
GO_0048023Biological processpositive regulation of melanin biosynthetic process
GO_0009637Biological processresponse to blue light
GO_0071492Biological processcellular response to UV-A
GO_1901857Biological processpositive regulation of cellular respiration
GO_0005886Cellular componentplasma membrane
GO_0001750Cellular componentphotoreceptor outer segment
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0008020Molecular functionG protein-coupled photoreceptor activity
GO_0005503Molecular functionall-trans retinal binding
GO_0005502Molecular function11-cis retinal binding
GO_0005515Molecular functionprotein binding
GO_0009881Molecular functionphotoreceptor activity

IV. Literature review

[source]
Gene nameOPN3
Protein nameAlternative protein OPN3
Opsin 3
Opsin-3 (Encephalopsin) (Panopsin)
SynonymshCG_1989351
ECPN
DescriptionFUNCTION: G-protein coupled receptor which selectively activates G proteins via ultraviolet A (UVA) light-mediated activation in the skin . Binds both 11-cis retinal and all-trans retinal . Regulates melanogenesis in melanocytes via inhibition of alpha-MSH-induced MC1R-mediated cAMP signaling, modulation of calcium flux, regulation of CAMK2 phosphorylation, and subsequently phosphorylation of CREB, p38, ERK and MITF in response to blue light . Plays a role in melanocyte survival through regulation of intracellular calcium levels and subsequent BCL2/RAF1 signaling . Additionally regulates apoptosis via cytochrome c release and subsequent activation of the caspase cascade . Required for TYR and DCT blue light-induced complex formation in melanocytes . Involved in keratinocyte differentiation in response to blue-light . Required for the UVA-mediated induction of calcium and mitogen-activated protein kinase signaling resulting in the expression of MMP1, MMP2, MMP3, MMP9 and TIMP1 in dermal fibroblasts . Plays a role in light-mediated glucose uptake, mitochondrial respiration and fatty acid metabolism in brown adipocyte tissues (By similarity). May be involved in photorelaxation of airway smooth muscle cells, via blue-light dependent GPCR signaling pathways (By similarity). .

AccessionsL8E9L4
ENST00000478849.1
ENST00000366554.3 [Q9H1Y3-1]
ENST00000469376.5
Q6GMT1
Q6P5W7
ENST00000490673.5
A0A1B0GUF8
Q9H1Y3