RGS7BP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009968Biological processnegative regulation of signal transduction
GO_0060078Biological processregulation of postsynaptic membrane potential
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0043204Cellular componentperikaryon
GO_0044327Cellular componentdendritic spine head
GO_0098978Cellular componentglutamatergic synapse
GO_0098839Cellular componentpostsynaptic density membrane
GO_0030424Cellular componentaxon
GO_0098794Cellular componentpostsynapse
GO_0043005Cellular componentneuron projection
GO_0042734Cellular componentpresynaptic membrane
GO_0005737Cellular componentcytoplasm
GO_0043198Cellular componentdendritic shaft
GO_0005634Cellular componentnucleus

IV. Literature review

[source]
Gene nameRGS7BP
Protein nameRegulator of G-protein signaling 7-binding protein (R7 family-binding protein)
SynonymsR7BP
DescriptionFUNCTION: Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cytoplasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation. .

AccessionsQ6MZT1
ENST00000334025.3