RGS19 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006914Biological processautophagy
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0045471Biological processresponse to ethanol
GO_0007264Biological processsmall GTPase-mediated signal transduction
GO_0009968Biological processnegative regulation of signal transduction
GO_0005903Cellular componentbrush border
GO_0030136Cellular componentclathrin-coated vesicle
GO_0005794Cellular componentGolgi apparatus
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0001965Molecular functionG-protein alpha-subunit binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRGS19
Protein nameRegulator of G-protein signaling 19 (RGS19) (G-alpha-interacting protein) (GAIP)
RGS19 protein
SynonymsGNAI3IP
GAIP
DescriptionFUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.

AccessionsENST00000332298.9
ENST00000395042.2
Q6I9S5
P49795