GPR34 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GPR34 at tissue level.

III. Associated gene sets

GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0035589Biological processG protein-coupled purinergic nucleotide receptor signaling pathway
GO_0005886Cellular componentplasma membrane
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0045028Molecular functionG protein-coupled purinergic nucleotide receptor activity

IV. Literature review

[source]
Gene nameGPR34
Protein nameG-protein-coupled receptor 34 splice variant
Probable G-protein coupled receptor 34
SynonymshCG_1818087
DescriptionFUNCTION: G-protein-coupled receptor of lysophosphatidylserine (LysoPS) that plays different roles in immune response . Acts a damage-sensing receptor that triggers tissue repair upon recognition of dying neutrophils (By similarity). Mechanistically, apoptotic neutrophils release lysophosphatydilserine that are recognized by type 3 innate lymphoid cells (ILC3s) via GPR34, which activates downstream PI3K-AKT and RAS-ERK signaling pathways leading to STAT3 activation and IL-22 production (By similarity). Plays an important role in microglial function, controlling morphology and phagocytosis (By similarity). .

AccessionsQ3SAH2
ENST00000378138.5
ENST00000378142.9
Q9UPC5
ENST00000649219.1
Q3SAH0
Q5VT14