GPR62 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GPR62 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GPR62 at tissue level.

III. Associated gene sets

GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0050850Biological processpositive regulation of calcium-mediated signaling
GO_0038035Biological processligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0010008Cellular componentendosome membrane
GO_0005768Cellular componentendosome
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_0004930Molecular functionG protein-coupled receptor activity
GO_1990763Molecular functionarrestin family protein binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGPR62
Protein nameG protein-coupled receptor 62
G-protein coupled receptor 62 (G-protein coupled receptor GPCR8) (hGPCR8) (G-protein coupled receptor KPG_005)
Synonyms
DescriptionFUNCTION: Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways . Has spontaneous activity for beta-arrestin recruitment . Shows a reciprocal modulation of signaling functions with the melatonin receptor MTNR1B most likely through receptor heteromerization . .

AccessionsQ8TAM0
Q9BZJ7
ENST00000322241.6