FZD10 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of FZD10 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FZD10 at tissue level.

III. Associated gene sets

GO_0071300Biological processcellular response to retinoic acid
GO_0030182Biological processneuron differentiation
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0035567Biological processnon-canonical Wnt signaling pathway
GO_0032956Biological processregulation of actin cytoskeleton organization
GO_0060070Biological processcanonical Wnt signaling pathway
GO_0046330Biological processpositive regulation of JNK cascade
GO_0009986Cellular componentcell surface
GO_0005654Cellular componentnucleoplasm
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0017147Molecular functionWnt-protein binding
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0042813Molecular functionWnt receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFZD10
Protein nameFrizzled homolog 10 (Drosophila)
Frizzled-10 (Fz-10) (hFz10) (FzE7) (CD antigen CD350)
Frizzled class receptor 10
Synonyms
DescriptionFUNCTION: Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). .

AccessionsQ9ULW2
F5H450
ENST00000229030.5
ENST00000539839.1
Q6NSL8