FFAR3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of FFAR3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FFAR3 at tissue level.

III. Associated gene sets

GO_0014061Biological processregulation of norepinephrine secretion
GO_0071398Biological processcellular response to fatty acid
GO_0032722Biological processpositive regulation of chemokine production
GO_0046626Biological processregulation of insulin receptor signaling pathway
GO_0046885Biological processregulation of hormone biosynthetic process
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0045776Biological processnegative regulation of blood pressure
GO_0006954Biological processinflammatory response
GO_0002879Biological processpositive regulation of acute inflammatory response to non-antigenic stimulus
GO_0007193Biological processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO_0002385Biological processmucosal immune response
GO_0090276Biological processregulation of peptide hormone secretion
GO_0002720Biological processpositive regulation of cytokine production involved in immune response
GO_0005886Cellular componentplasma membrane
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0005515Molecular functionprotein binding
GO_0008289Molecular functionlipid binding

IV. Literature review

[source]
Gene nameFFAR3
Protein nameFree fatty acid receptor 3 (G-protein coupled receptor 41)
Free fatty acid receptor 3 (G-protein coupled receptor)
G-protein coupled receptor
SynonymsGPR41
DescriptionFUNCTION: G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation . Activated by SCFAs and by beta-hydroxybutyrate, a ketone body produced by the liver upon starvation, it inhibits N-type calcium channels and modulates the activity of sympathetic neurons through a signaling cascade involving the beta and gamma subunits of its coupled G protein, phospholipase C and MAP kinases. Thereby, it may regulate energy expenditure through the control of the sympathetic nervous system that controls for instance heart rate. Upon activation by SCFAs accumulating in the intestine, it may also signal to the brain via neural circuits which in turn would regulate intestinal gluconeogenesis. May also control the production of hormones involved in whole-body energy homeostasis. May for instance, regulate blood pressure through renin secretion. May also regulate secretion of the PYY peptide by enteroendocrine cells and control gut motility, intestinal transit rate, and the harvesting of energy from SCFAs produced by gut microbiota. May also indirectly regulate the production of LEP/Leptin, a hormone acting on the CNS to inhibit food intake, in response to the presence of short-chain fatty acids in the intestine. Finally, may also play a role in glucose homeostasis. Besides its role in energy homeostasis, may play a role in intestinal immunity. May mediate the activation of the inflammatory and immune response by SCFAs in the gut, regulating the rapid production of chemokines and cytokines by intestinal epithelial cells. Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably propionate, butyrate and pentanoate while acetate is a poor activator . .

AccessionsENST00000327809.5
A0A0K0PV71
A0A0K0PUW4
A0A0K0PW26
A0A0K0PV66
A0A0K0PUW7
A0A0K0PUW9
A0A0K0PUV2
B0M0K0
A0A0K0PUX8
A0A0K0PUV6
O14843
ENST00000594310.1