I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| pancreatic A cell | 3 studies | 75% ± 23% | |
| pancreatic D cell | 3 studies | 100% ± 0% | |
| type B pancreatic cell | 3 studies | 78% ± 17% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| pancreatic A cell | 3 studies | 75% ± 23% | |
| pancreatic D cell | 3 studies | 100% ± 0% | |
| type B pancreatic cell | 3 studies | 78% ± 17% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| pancreas | 3 studies | 69% ± 28% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| pancreas | 99% | 5780.36 | 326 / 328 | 81% | 2579.96 | 144 / 178 |
| brain | 68% | 2767.00 | 1789 / 2642 | 48% | 35.81 | 340 / 705 |
| stomach | 77% | 6184.03 | 277 / 359 | 12% | 11.25 | 33 / 286 |
| ovary | 3% | 20.69 | 5 / 180 | 70% | 685.39 | 300 / 430 |
| adrenal gland | 19% | 231.66 | 48 / 258 | 43% | 1757.73 | 98 / 230 |
| intestine | 39% | 361.12 | 376 / 966 | 9% | 37.69 | 46 / 527 |
| kidney | 3% | 21.62 | 3 / 89 | 31% | 278.01 | 276 / 901 |
| bladder | 5% | 32.86 | 1 / 21 | 6% | 20.60 | 31 / 504 |
| uterus | 0% | 0 | 0 / 170 | 10% | 61.90 | 47 / 459 |
| lung | 1% | 3.38 | 3 / 578 | 7% | 57.11 | 82 / 1155 |
| esophagus | 1% | 9.67 | 20 / 1445 | 5% | 29.40 | 10 / 183 |
| prostate | 2% | 13.59 | 5 / 245 | 2% | 2.08 | 10 / 502 |
| thymus | 2% | 9.96 | 11 / 653 | 2% | 2.36 | 12 / 605 |
| breast | 1% | 5.14 | 5 / 459 | 1% | 0.45 | 9 / 1118 |
| liver | 0% | 0 | 0 / 226 | 2% | 18.71 | 7 / 406 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.81 | 1 / 80 |
| heart | 1% | 4.56 | 6 / 861 | 0% | 0 | 0 / 0 |
| skin | 0% | 3.38 | 8 / 1809 | 0% | 0 | 0 / 472 |
| spleen | 0% | 1.40 | 1 / 241 | 0% | 0 | 0 / 0 |
| adipose | 0% | 3.23 | 4 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 0.73 | 2 / 1335 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007584 | Biological process | response to nutrient |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0038170 | Biological process | somatostatin signaling pathway |
| GO_0043200 | Biological process | response to amino acid |
| GO_0008628 | Biological process | hormone-mediated apoptotic signaling pathway |
| GO_0007586 | Biological process | digestion |
| GO_0099072 | Biological process | regulation of postsynaptic membrane neurotransmitter receptor levels |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_0010447 | Biological process | response to acidic pH |
| GO_0006972 | Biological process | hyperosmotic response |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0030334 | Biological process | regulation of cell migration |
| GO_0007268 | Biological process | chemical synaptic transmission |
| GO_0010243 | Biological process | response to organonitrogen compound |
| GO_0048545 | Biological process | response to steroid hormone |
| GO_0009410 | Biological process | response to xenobiotic stimulus |
| GO_0007166 | Biological process | cell surface receptor signaling pathway |
| GO_0098992 | Cellular component | neuronal dense core vesicle |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0098982 | Cellular component | GABA-ergic synapse |
| GO_0005179 | Molecular function | hormone activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SST |
| Protein name | Somatostatin (Growth hormone release-inhibiting factor) [Cleaved into: Somatostatin-28; Somatostatin-14 (SST-14); Neuronostatin (NST)] |
| Synonyms | |
| Description | FUNCTION: [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin. .; FUNCTION: [Neuronostatin]: May enhance low-glucose-induced glucagon release by pancreatic alpha cells (By similarity). This effect may be mediated by binding to GPR107 and PKA activation (By similarity). May regulate cardiac contractile function (By similarity). May compromise cardiomyocyte viability (By similarity). In the central nervous system, may impair memory retention and may affect hippocampal excitability (By similarity). May also have anxiolytic and anorexigenic effects (By similarity). May play a role in arterial pressure regulation (By similarity). May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH. Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH . . |
| Accessions | ENST00000287641.4 P61278 |
