Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 12 studies | 21% ± 6% | |
| capillary endothelial cell | 6 studies | 21% ± 5% | |
| glomerular endothelial cell | 3 studies | 27% ± 3% | |
| vein endothelial cell | 3 studies | 29% ± 11% | |
| endothelial cell of sinusoid | 3 studies | 32% ± 20% |
Insufficient scRNA-seq data for expression of NPR1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 100% | 6838.42 | 180 / 180 | 99% | 120.04 | 424 / 430 |
| kidney | 100% | 7180.02 | 89 / 89 | 94% | 40.67 | 844 / 901 |
| adrenal gland | 94% | 2178.84 | 243 / 258 | 88% | 18.66 | 202 / 230 |
| thymus | 99% | 3808.91 | 646 / 653 | 73% | 7.99 | 442 / 605 |
| breast | 100% | 11292.77 | 458 / 459 | 62% | 6.35 | 690 / 1118 |
| lung | 100% | 6421.28 | 577 / 578 | 49% | 5.61 | 564 / 1155 |
| uterus | 98% | 5664.50 | 166 / 170 | 39% | 9.85 | 181 / 459 |
| bladder | 95% | 3227.00 | 20 / 21 | 30% | 3.22 | 152 / 504 |
| esophagus | 75% | 3279.62 | 1081 / 1445 | 30% | 2.56 | 55 / 183 |
| intestine | 81% | 2373.86 | 779 / 966 | 21% | 2.05 | 112 / 527 |
| adipose | 100% | 12074.85 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 99% | 13740.21 | 1324 / 1335 | 0% | 0 | 0 / 0 |
| heart | 90% | 2343.33 | 774 / 861 | 0% | 0 | 0 / 0 |
| stomach | 54% | 1696.50 | 194 / 359 | 35% | 2.95 | 99 / 286 |
| skin | 43% | 910.85 | 775 / 1809 | 44% | 6.83 | 207 / 472 |
| pancreas | 13% | 182.75 | 42 / 328 | 70% | 7.39 | 124 / 178 |
| liver | 14% | 240.79 | 32 / 226 | 63% | 5.10 | 256 / 406 |
| prostate | 46% | 869.73 | 113 / 245 | 30% | 1.87 | 152 / 502 |
| brain | 0% | 3.97 | 6 / 2642 | 19% | 1.88 | 134 / 705 |
| muscle | 14% | 202.36 | 116 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 14% | 0.82 | 4 / 29 |
| spleen | 11% | 189.17 | 27 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 11% | 1.04 | 5 / 45 |
| peripheral blood | 4% | 80.62 | 41 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0019934 | Biological process | cGMP-mediated signaling |
| GO_0006182 | Biological process | cGMP biosynthetic process |
| GO_0043114 | Biological process | regulation of vascular permeability |
| GO_0008217 | Biological process | regulation of blood pressure |
| GO_0042417 | Biological process | dopamine metabolic process |
| GO_0097746 | Biological process | blood vessel diameter maintenance |
| GO_0016525 | Biological process | negative regulation of angiogenesis |
| GO_0007168 | Biological process | receptor guanylyl cyclase signaling pathway |
| GO_0007589 | Biological process | body fluid secretion |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0048662 | Biological process | negative regulation of smooth muscle cell proliferation |
| GO_0035815 | Biological process | positive regulation of renal sodium excretion |
| GO_0030308 | Biological process | negative regulation of cell growth |
| GO_0010753 | Biological process | positive regulation of cGMP-mediated signaling |
| GO_0035810 | Biological process | positive regulation of urine volume |
| GO_0007166 | Biological process | cell surface receptor signaling pathway |
| GO_0043235 | Cellular component | receptor complex |
| GO_0005886 | Cellular component | plasma membrane |
| GO_1990620 | Cellular component | ANPR-A receptor complex |
| GO_0004016 | Molecular function | adenylate cyclase activity |
| GO_0042562 | Molecular function | hormone binding |
| GO_0001653 | Molecular function | peptide receptor activity |
| GO_0017046 | Molecular function | peptide hormone binding |
| GO_0004672 | Molecular function | protein kinase activity |
| GO_0005525 | Molecular function | GTP binding |
| GO_0008528 | Molecular function | G protein-coupled peptide receptor activity |
| GO_0016941 | Molecular function | natriuretic peptide receptor activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0004383 | Molecular function | guanylate cyclase activity |
| Gene name | NPR1 |
| Protein name | Alternative protein NPR1 Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A) Natriuretic peptide receptor A/guanylate cyclase A (Atrionatriuretic peptide receptor A) variant 2 |
| Synonyms | ANPRA |
| Description | FUNCTION: Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand. . |
| Accessions | L8E7A1 ENST00000368680.4 B0ZBF1 P16066 |
