PDE3B | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
CD4-positive, alpha-beta T cell	16 studies	30% ± 13%	Explore
T cell	14 studies	25% ± 10%	Explore
microglial cell	13 studies	51% ± 15%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	29% ± 13%	Explore
regulatory T cell	12 studies	27% ± 12%	Explore
CD8-positive, alpha-beta T cell	12 studies	30% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	22% ± 5%	Explore
adipocyte	10 studies	85% ± 10%	Explore
glutamatergic neuron	9 studies	44% ± 20%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	34% ± 10%	Explore
astrocyte	9 studies	37% ± 20%	Explore
endothelial cell	9 studies	29% ± 13%	Explore
macrophage	9 studies	33% ± 13%	Explore
oligodendrocyte precursor cell	9 studies	31% ± 5%	Explore
fibroblast	9 studies	31% ± 6%	Explore
GABAergic neuron	8 studies	44% ± 24%	Explore
mucosal invariant T cell	8 studies	24% ± 9%	Explore
gamma-delta T cell	8 studies	27% ± 9%	Explore
mast cell	7 studies	32% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	32% ± 11%	Explore
interneuron	6 studies	49% ± 24%	Explore
monocyte	6 studies	36% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	23% ± 3%	Explore
mature NK T cell	5 studies	24% ± 13%	Explore
hepatocyte	4 studies	63% ± 26%	Explore
neuron	4 studies	41% ± 21%	Explore
epithelial cell	4 studies	21% ± 5%	Explore
granule cell	4 studies	44% ± 15%	Explore
cardiac muscle cell	4 studies	27% ± 4%	Explore
dendritic cell	4 studies	24% ± 5%	Explore
myeloid cell	4 studies	31% ± 6%	Explore
natural killer cell	4 studies	26% ± 5%	Explore
T follicular helper cell	4 studies	23% ± 2%	Explore
pancreatic A cell	3 studies	41% ± 25%	Explore
GABAergic interneuron	3 studies	42% ± 4%	Explore
capillary endothelial cell	3 studies	38% ± 10%	Explore
glycinergic amacrine cell	3 studies	23% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	25% ± 13%	Explore
alveolar macrophage	3 studies	43% ± 8%	Explore
myofibroblast cell	3 studies	29% ± 10%	Explore
smooth muscle cell	3 studies	23% ± 2%	Explore
leukocyte	3 studies	49% ± 15%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	12 studies	35% ± 20%	Explore
peripheral blood	5 studies	19% ± 3%	Explore
liver	4 studies	34% ± 19%	Explore
heart	3 studies	21% ± 4%	Explore
adipose	3 studies	41% ± 23%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	98%	1618.27	240 / 245	99%	18.32	497 / 502
liver	100%	2333.18	225 / 226	85%	6.74	347 / 406
intestine	99%	5417.47	959 / 966	85%	5.76	449 / 527
lung	100%	2427.47	577 / 578	75%	4.19	868 / 1155
pancreas	98%	1186.46	323 / 328	67%	4.98	119 / 178
bladder	95%	2628.14	20 / 21	66%	3.85	332 / 504
esophagus	72%	913.04	1044 / 1445	77%	4.70	141 / 183
stomach	65%	594.04	234 / 359	77%	5.19	220 / 286
brain	60%	809.02	1595 / 2642	72%	2.84	506 / 705
breast	76%	3558.49	348 / 459	35%	1.67	392 / 1118
spleen	100%	1619.86	241 / 241	0%	0	0 / 0
adipose	99%	5401.87	1190 / 1204	0%	0	0 / 0
skin	5%	39.61	97 / 1809	80%	12.29	378 / 472
peripheral blood	85%	1332.16	788 / 929	0%	0	0 / 0
heart	79%	712.11	680 / 861	0%	0	0 / 0
kidney	34%	233.37	30 / 89	26%	1.55	232 / 901
lymph node	0%	0	0 / 0	59%	4.10	17 / 29
tonsil	0%	0	0 / 0	56%	2.27	25 / 45
adrenal gland	4%	25.74	10 / 258	45%	2.71	103 / 230
blood vessel	48%	732.07	635 / 1335	0%	0	0 / 0
uterus	7%	55.07	12 / 170	29%	1.63	135 / 459
thymus	17%	136.30	113 / 653	8%	0.30	46 / 605
eye	0%	0	0 / 0	21%	1.24	17 / 80
ovary	3%	14.86	5 / 180	4%	0.18	19 / 430
muscle	3%	20.00	22 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0001525	Biological process	angiogenesis
GO_0032869	Biological process	cellular response to insulin stimulus
GO_0007162	Biological process	negative regulation of cell adhesion
GO_0019933	Biological process	cAMP-mediated signaling
GO_0033629	Biological process	negative regulation of cell adhesion mediated by integrin
GO_0016525	Biological process	negative regulation of angiogenesis
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0050995	Biological process	negative regulation of lipid catabolic process
GO_0106072	Biological process	negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0032045	Cellular component	guanyl-nucleotide exchange factor complex
GO_0016020	Cellular component	membrane
GO_0005794	Cellular component	Golgi apparatus
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0004114	Molecular function	3',5'-cyclic-nucleotide phosphodiesterase activity
GO_0004119	Molecular function	cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
GO_0047555	Molecular function	3',5'-cyclic-GMP phosphodiesterase activity
GO_0046872	Molecular function	metal ion binding
GO_0043422	Molecular function	protein kinase B binding
GO_0004115	Molecular function	3',5'-cyclic-AMP phosphodiesterase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PDE3B
Protein name	cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (EC 3.1.4.17) (CGIPDE1) (CGIP1) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) Phosphodiesterase (EC 3.1.4.-)
Synonyms
Description	FUNCTION: Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process . Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling . Controls cardiac contractility by reducing cAMP concentration in cardiocytes (By similarity). .
Accessions	A7E2E5 Q13370 ENST00000282096.9 [Q13370-1] ENST00000455098.2 [Q13370-2]

PDE3B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review