FRS2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001702Biological processgastrulation with mouth forming second
GO_0060527Biological processprostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO_0001759Biological processorgan induction
GO_0070372Biological processregulation of ERK1 and ERK2 cascade
GO_0030900Biological processforebrain development
GO_0008595Biological processanterior/posterior axis specification, embryo
GO_0003281Biological processventricular septum development
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0070307Biological processlens fiber cell development
GO_2000726Biological processnegative regulation of cardiac muscle cell differentiation
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0007185Biological processcell surface receptor protein tyrosine phosphatase signaling pathway
GO_0042981Biological processregulation of apoptotic process
GO_0050678Biological processregulation of epithelial cell proliferation
GO_0046619Biological processlens placode formation involved in camera-type eye formation
GO_1904707Biological processpositive regulation of vascular associated smooth muscle cell proliferation
GO_0008543Biological processfibroblast growth factor receptor signaling pathway
GO_0007405Biological processneuroblast proliferation
GO_0005886Cellular componentplasma membrane
GO_0012505Cellular componentendomembrane system
GO_0016020Cellular componentmembrane
GO_0005911Cellular componentcell-cell junction
GO_0005829Cellular componentcytosol
GO_0005912Cellular componentadherens junction
GO_0005737Cellular componentcytoplasm
GO_0005068Molecular functiontransmembrane receptor protein tyrosine kinase adaptor activity
GO_0005104Molecular functionfibroblast growth factor receptor binding
GO_0005515Molecular functionprotein binding
GO_0019211Molecular functionphosphatase activator activity
GO_0005168Molecular functionneurotrophin TRKA receptor binding

IV. Literature review

[source]
Gene nameFRS2
Protein nameFibroblast growth factor receptor substrate 2
Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1)
Synonyms
DescriptionFUNCTION: Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. .

AccessionsENST00000548154.5
L7RTG7
ENST00000550316.5
F8VX65
F8VYZ7
ENST00000547219.5
F8VP54
F8VZ12
ENST00000549921.6
ENST00000550169.5
A0A0G2JL00
ENST00000550389.5
ENST00000550937.5
ENST00000397997.6
Q8WU20
ENST00000549092.5
F8VS98
F8VW66
ENST00000551325.1
F8VZI4
ENST00000547414.5