Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 14 studies | 38% ± 18% | |
endothelial cell | 13 studies | 25% ± 10% | |
oligodendrocyte | 11 studies | 28% ± 10% | |
fibroblast | 9 studies | 24% ± 7% | |
oligodendrocyte precursor cell | 9 studies | 30% ± 14% | |
GABAergic neuron | 8 studies | 39% ± 21% | |
glutamatergic neuron | 8 studies | 41% ± 26% | |
microglial cell | 8 studies | 24% ± 7% | |
adipocyte | 7 studies | 31% ± 7% | |
interneuron | 6 studies | 37% ± 23% | |
macrophage | 6 studies | 33% ± 2% | |
epithelial cell | 5 studies | 30% ± 12% | |
endothelial cell of lymphatic vessel | 5 studies | 23% ± 4% | |
smooth muscle cell | 5 studies | 21% ± 2% | |
type I pneumocyte | 5 studies | 22% ± 6% | |
type II pneumocyte | 5 studies | 20% ± 6% | |
granule cell | 4 studies | 27% ± 9% | |
cardiac muscle cell | 4 studies | 24% ± 1% | |
pericyte | 4 studies | 21% ± 5% | |
neuron | 3 studies | 33% ± 14% | |
GABAergic interneuron | 3 studies | 22% ± 3% | |
retinal rod cell | 3 studies | 19% ± 3% | |
myeloid cell | 3 studies | 23% ± 3% | |
hepatocyte | 3 studies | 37% ± 15% | |
retinal pigment epithelial cell | 3 studies | 34% ± 15% | |
connective tissue cell | 3 studies | 19% ± 3% | |
ependymal cell | 3 studies | 39% ± 14% | |
club cell | 3 studies | 23% ± 8% | |
monocyte | 3 studies | 21% ± 2% | |
lymphocyte | 3 studies | 18% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 1535.33 | 1444 / 1445 | 100% | 28.73 | 183 / 183 |
ovary | 100% | 2100.07 | 180 / 180 | 100% | 20.79 | 429 / 430 |
lung | 100% | 1535.08 | 578 / 578 | 100% | 16.47 | 1151 / 1155 |
brain | 100% | 1947.23 | 2641 / 2642 | 100% | 33.24 | 702 / 705 |
breast | 100% | 2097.16 | 459 / 459 | 99% | 41.21 | 1105 / 1118 |
thymus | 100% | 1612.25 | 653 / 653 | 97% | 14.67 | 587 / 605 |
prostate | 100% | 1395.60 | 245 / 245 | 97% | 13.46 | 487 / 502 |
uterus | 100% | 2142.80 | 170 / 170 | 96% | 12.69 | 439 / 459 |
bladder | 100% | 1753.62 | 21 / 21 | 95% | 15.12 | 480 / 504 |
stomach | 100% | 1113.42 | 359 / 359 | 95% | 16.53 | 272 / 286 |
intestine | 100% | 1532.39 | 966 / 966 | 95% | 12.41 | 499 / 527 |
adrenal gland | 100% | 1821.01 | 258 / 258 | 93% | 12.73 | 215 / 230 |
pancreas | 97% | 704.53 | 318 / 328 | 96% | 11.34 | 170 / 178 |
kidney | 100% | 890.08 | 89 / 89 | 92% | 12.31 | 832 / 901 |
skin | 100% | 1825.17 | 1809 / 1809 | 91% | 14.77 | 428 / 472 |
liver | 100% | 820.63 | 226 / 226 | 76% | 7.05 | 308 / 406 |
blood vessel | 100% | 1836.62 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 1066.90 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 5.61 | 1 / 1 |
adipose | 100% | 1833.41 | 1203 / 1204 | 0% | 0 | 0 / 0 |
muscle | 100% | 926.60 | 802 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 96% | 17.05 | 43 / 45 |
heart | 95% | 879.52 | 822 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 70% | 6.37 | 56 / 80 |
lymph node | 0% | 0 | 0 / 0 | 55% | 3.72 | 16 / 29 |
peripheral blood | 52% | 397.04 | 486 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0001702 | Biological process | gastrulation with mouth forming second |
GO_0060527 | Biological process | prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis |
GO_0001759 | Biological process | organ induction |
GO_0070372 | Biological process | regulation of ERK1 and ERK2 cascade |
GO_0030900 | Biological process | forebrain development |
GO_0008595 | Biological process | anterior/posterior axis specification, embryo |
GO_0003281 | Biological process | ventricular septum development |
GO_0043410 | Biological process | positive regulation of MAPK cascade |
GO_0070307 | Biological process | lens fiber cell development |
GO_2000726 | Biological process | negative regulation of cardiac muscle cell differentiation |
GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
GO_0007185 | Biological process | cell surface receptor protein tyrosine phosphatase signaling pathway |
GO_0042981 | Biological process | regulation of apoptotic process |
GO_0050678 | Biological process | regulation of epithelial cell proliferation |
GO_0046619 | Biological process | lens placode formation involved in camera-type eye formation |
GO_1904707 | Biological process | positive regulation of vascular associated smooth muscle cell proliferation |
GO_0008543 | Biological process | fibroblast growth factor receptor signaling pathway |
GO_0007405 | Biological process | neuroblast proliferation |
GO_0005886 | Cellular component | plasma membrane |
GO_0012505 | Cellular component | endomembrane system |
GO_0016020 | Cellular component | membrane |
GO_0005911 | Cellular component | cell-cell junction |
GO_0005829 | Cellular component | cytosol |
GO_0005912 | Cellular component | adherens junction |
GO_0005737 | Cellular component | cytoplasm |
GO_0005068 | Molecular function | transmembrane receptor protein tyrosine kinase adaptor activity |
GO_0005104 | Molecular function | fibroblast growth factor receptor binding |
GO_0005515 | Molecular function | protein binding |
GO_0019211 | Molecular function | phosphatase activator activity |
GO_0005168 | Molecular function | neurotrophin TRKA receptor binding |
Gene name | FRS2 |
Protein name | Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1) |
Synonyms | |
Description | FUNCTION: Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. . |
Accessions | ENST00000548154.5 L7RTG7 ENST00000550316.5 F8VX65 F8VYZ7 ENST00000547219.5 F8VP54 F8VZ12 ENST00000549921.6 ENST00000550169.5 A0A0G2JL00 ENST00000550389.5 ENST00000550937.5 ENST00000397997.6 Q8WU20 ENST00000549092.5 F8VS98 F8VW66 ENST00000551325.1 F8VZI4 ENST00000547414.5 |