TULP3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0061512Biological processprotein localization to cilium
GO_0060831Biological processsmoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO_0042733Biological processembryonic digit morphogenesis
GO_0021953Biological processcentral nervous system neuron differentiation
GO_0045879Biological processnegative regulation of smoothened signaling pathway
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0008277Biological processregulation of G protein-coupled receptor signaling pathway
GO_0060434Biological processbronchus morphogenesis
GO_0001843Biological processneural tube closure
GO_0006355Biological processregulation of DNA-templated transcription
GO_0031076Biological processembryonic camera-type eye development
GO_0048702Biological processembryonic neurocranium morphogenesis
GO_0009952Biological processanterior/posterior pattern specification
GO_0007420Biological processbrain development
GO_0061548Biological processganglion development
GO_0060348Biological processbone development
GO_0005730Cellular componentnucleolus
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0097731Cellular component9+0 non-motile cilium
GO_0005654Cellular componentnucleoplasm
GO_0005930Cellular componentaxoneme
GO_0005929Cellular componentcilium
GO_0097546Cellular componentciliary base
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0120160Molecular functionintraciliary transport particle A binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0035091Molecular functionphosphatidylinositol binding
GO_0001664Molecular functionG protein-coupled receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTULP3
Protein nameTUB like protein 3
Tubby-related protein 3 (Tubby-like protein 3)
SynonymsTUBL3
DescriptionFUNCTION: Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. During adipogenesis, regulates ciliary trafficking of FFAR4 in preadipocytes. .

AccessionsENST00000397132.6 [O75386-2]
F5H7B9
H0YG12
ENST00000538354.5
ENST00000541678.5
H0YFU8
ENST00000545331.5
O75386
ENST00000540184.5 [O75386-3]
F5GWL5
ENST00000538704.1
ENST00000448120.7 [O75386-1]
ENST00000544943.5