Insufficient scRNA-seq data for expression of VIP at single-cell level.
Insufficient scRNA-seq data for expression of VIP at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| intestine | 99% | 2915.97 | 957 / 966 | 54% | 5.85 | 284 / 527 |
| stomach | 57% | 1460.58 | 206 / 359 | 45% | 5.89 | 128 / 286 |
| brain | 58% | 465.34 | 1532 / 2642 | 43% | 2.14 | 300 / 705 |
| spleen | 100% | 704.48 | 241 / 241 | 0% | 0 | 0 / 0 |
| pancreas | 31% | 92.14 | 102 / 328 | 63% | 7.58 | 113 / 178 |
| thymus | 71% | 170.20 | 466 / 653 | 15% | 0.24 | 91 / 605 |
| lung | 79% | 241.13 | 455 / 578 | 7% | 0.76 | 84 / 1155 |
| bladder | 52% | 89.05 | 11 / 21 | 23% | 2.35 | 114 / 504 |
| esophagus | 62% | 1115.38 | 893 / 1445 | 13% | 0.43 | 23 / 183 |
| adrenal gland | 26% | 101.10 | 68 / 258 | 35% | 56.06 | 81 / 230 |
| kidney | 44% | 86.37 | 39 / 89 | 16% | 0.36 | 146 / 901 |
| uterus | 55% | 131.41 | 93 / 170 | 0% | 0.01 | 2 / 459 |
| breast | 52% | 111.47 | 239 / 459 | 1% | 0.02 | 14 / 1118 |
| adipose | 50% | 119.03 | 608 / 1204 | 0% | 0 | 0 / 0 |
| prostate | 36% | 166.67 | 88 / 245 | 7% | 0.99 | 35 / 502 |
| heart | 42% | 85.61 | 365 / 861 | 0% | 0 | 0 / 0 |
| ovary | 12% | 23.83 | 22 / 180 | 0% | 0.06 | 1 / 430 |
| liver | 6% | 9.72 | 14 / 226 | 6% | 0.23 | 23 / 406 |
| blood vessel | 9% | 15.82 | 119 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 3% | 4.17 | 24 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 2% | 0.03 | 1 / 45 |
| skin | 1% | 2.16 | 23 / 1809 | 0% | 0.06 | 2 / 472 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007589 | Biological process | body fluid secretion |
| GO_0045732 | Biological process | positive regulation of protein catabolic process |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0032880 | Biological process | regulation of protein localization |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0007189 | Biological process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| GO_0048242 | Biological process | epinephrine secretion |
| GO_0048255 | Biological process | mRNA stabilization |
| GO_0070459 | Biological process | prolactin secretion |
| GO_0005576 | Cellular component | extracellular region |
| GO_0043005 | Cellular component | neuron projection |
| GO_0005179 | Molecular function | hormone activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0051428 | Molecular function | peptide hormone receptor binding |
| GO_0005184 | Molecular function | neuropeptide hormone activity |
| Gene name | VIP |
| Protein name | VIP peptides [Cleaved into: Intestinal peptide PHV-42 (Peptide histidine valine 42); Intestinal peptide PHM-27 (Peptide histidine methioninamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide)] Vasoactive intestinal peptide |
| Synonyms | |
| Description | FUNCTION: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder. .; FUNCTION: PHM and PHV also cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin. . FUNCTION: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder. . |
| Accessions | ENST00000367244.8 [P01282-1] H0Y763 P01282 ENST00000367243.7 [P01282-2] ENST00000431366.1 |