GRK6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009966Biological processregulation of signal transduction
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0016055Biological processWnt signaling pathway
GO_0006468Biological processprotein phosphorylation
GO_0008277Biological processregulation of G protein-coupled receptor signaling pathway
GO_0016020Cellular componentmembrane
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0004703Molecular functionG protein-coupled receptor kinase activity
GO_0047696Molecular functionbeta-adrenergic receptor kinase activity
GO_0005515Molecular functionprotein binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameGRK6
Protein nameG protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6)
G protein-coupled receptor kinase 6
G protein-coupled receptor kinase (EC 2.7.11.-)
SynonymsGPRK6
DescriptionFUNCTION: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). .

AccessionsENST00000355472.10 [P43250-1]
ENST00000511244.5
D6R9V4
H0Y967
ENST00000502598.5
Q96AD6
ENST00000506296.5
P43250
D6RHC7
ENST00000508705.1
ENST00000528793.5 [P43250-2]
ENST00000507633.5
ENST00000355958.9 [P43250-3]
D6RDA3
ENST00000512684.1
D6RC88
ENST00000393576.7
F8W9W2
D6RHX8