Name | Number of supported studies | Average coverage | |
---|---|---|---|
B cell | 12 studies | 23% ± 8% | |
non-classical monocyte | 10 studies | 32% ± 18% | |
natural killer cell | 9 studies | 23% ± 6% | |
CD4-positive, alpha-beta T cell | 9 studies | 25% ± 9% | |
CD16-negative, CD56-bright natural killer cell, human | 8 studies | 24% ± 6% | |
memory B cell | 8 studies | 20% ± 2% | |
CD16-positive, CD56-dim natural killer cell, human | 7 studies | 24% ± 7% | |
classical monocyte | 7 studies | 28% ± 14% | |
T cell | 6 studies | 23% ± 9% | |
gamma-delta T cell | 6 studies | 24% ± 6% | |
naive B cell | 6 studies | 22% ± 5% | |
plasmablast | 5 studies | 37% ± 20% | |
CD8-positive, alpha-beta T cell | 5 studies | 29% ± 5% | |
CD8-positive, alpha-beta memory T cell | 5 studies | 23% ± 4% | |
regulatory T cell | 5 studies | 20% ± 5% | |
plasma cell | 4 studies | 30% ± 14% | |
CD4-positive, alpha-beta memory T cell | 4 studies | 21% ± 4% | |
epithelial cell | 4 studies | 19% ± 2% | |
naive thymus-derived CD4-positive, alpha-beta T cell | 3 studies | 25% ± 7% | |
myeloid cell | 3 studies | 21% ± 3% | |
effector memory CD4-positive, alpha-beta T cell | 3 studies | 27% ± 11% | |
T follicular helper cell | 3 studies | 22% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
ovary | 100% | 1372.78 | 180 / 180 | 100% | 45.26 | 430 / 430 |
uterus | 100% | 1845.78 | 170 / 170 | 100% | 43.69 | 459 / 459 |
esophagus | 100% | 2132.82 | 1444 / 1445 | 100% | 41.25 | 183 / 183 |
skin | 100% | 1944.64 | 1808 / 1809 | 100% | 50.86 | 471 / 472 |
stomach | 100% | 1599.45 | 359 / 359 | 100% | 40.47 | 285 / 286 |
intestine | 100% | 2583.14 | 966 / 966 | 100% | 47.05 | 525 / 527 |
lung | 100% | 2821.51 | 578 / 578 | 100% | 35.53 | 1150 / 1155 |
breast | 100% | 1718.85 | 459 / 459 | 100% | 35.59 | 1113 / 1118 |
prostate | 100% | 2209.36 | 245 / 245 | 99% | 33.82 | 499 / 502 |
thymus | 100% | 1434.33 | 652 / 653 | 100% | 30.13 | 602 / 605 |
bladder | 100% | 1913.90 | 21 / 21 | 99% | 39.81 | 500 / 504 |
brain | 99% | 1453.46 | 2614 / 2642 | 100% | 24.71 | 705 / 705 |
adrenal gland | 100% | 1301.81 | 258 / 258 | 98% | 23.66 | 225 / 230 |
kidney | 100% | 1212.20 | 89 / 89 | 97% | 18.79 | 878 / 901 |
pancreas | 97% | 911.29 | 318 / 328 | 100% | 34.01 | 178 / 178 |
liver | 95% | 773.92 | 215 / 226 | 98% | 19.84 | 398 / 406 |
adipose | 100% | 1617.40 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 24.29 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 101.63 | 29 / 29 |
peripheral blood | 100% | 14488.52 | 929 / 929 | 0% | 0 | 0 / 0 |
spleen | 100% | 7931.51 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 57.04 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 14.72 | 1 / 1 |
blood vessel | 100% | 1625.15 | 1333 / 1335 | 0% | 0 | 0 / 0 |
muscle | 99% | 1090.29 | 792 / 803 | 0% | 0 | 0 / 0 |
heart | 97% | 931.66 | 832 / 861 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0009966 | Biological process | regulation of signal transduction |
GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
GO_0016055 | Biological process | Wnt signaling pathway |
GO_0006468 | Biological process | protein phosphorylation |
GO_0008277 | Biological process | regulation of G protein-coupled receptor signaling pathway |
GO_0016020 | Cellular component | membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0004703 | Molecular function | G protein-coupled receptor kinase activity |
GO_0047696 | Molecular function | beta-adrenergic receptor kinase activity |
GO_0005515 | Molecular function | protein binding |
GO_0005524 | Molecular function | ATP binding |
Gene name | GRK6 |
Protein name | G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) G protein-coupled receptor kinase 6 G protein-coupled receptor kinase (EC 2.7.11.-) |
Synonyms | GPRK6 |
Description | FUNCTION: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). . |
Accessions | ENST00000355472.10 [P43250-1] ENST00000511244.5 D6R9V4 H0Y967 ENST00000502598.5 Q96AD6 ENST00000506296.5 P43250 D6RHC7 ENST00000508705.1 ENST00000528793.5 [P43250-2] ENST00000507633.5 ENST00000355958.9 [P43250-3] D6RDA3 ENST00000512684.1 D6RC88 ENST00000393576.7 F8W9W2 D6RHX8 |