PDE3A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019934Biological processcGMP-mediated signaling
GO_0097190Biological processapoptotic signaling pathway
GO_0071560Biological processcellular response to transforming growth factor beta stimulus
GO_0043116Biological processnegative regulation of vascular permeability
GO_0019933Biological processcAMP-mediated signaling
GO_0071321Biological processcellular response to cGMP
GO_0001556Biological processoocyte maturation
GO_0060700Biological processregulation of ribonuclease activity
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0043066Biological processnegative regulation of apoptotic process
GO_0040020Biological processregulation of meiotic nuclear division
GO_0043401Biological processsteroid hormone receptor signaling pathway
GO_0060282Biological processpositive regulation of oocyte development
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0043951Biological processnegative regulation of cAMP-mediated signaling
GO_0006629Biological processlipid metabolic process
GO_0106072Biological processnegative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0043117Biological processpositive regulation of vascular permeability
GO_0016020Cellular componentmembrane
GO_0005829Cellular componentcytosol
GO_0004114Molecular function3',5'-cyclic-nucleotide phosphodiesterase activity
GO_0099130Molecular functionestrogen binding
GO_0004119Molecular functioncGMP-inhibited cyclic-nucleotide phosphodiesterase activity
GO_0047555Molecular function3',5'-cyclic-GMP phosphodiesterase activity
GO_0046872Molecular functionmetal ion binding
GO_0004115Molecular function3',5'-cyclic-AMP phosphodiesterase activity
GO_0005515Molecular functionprotein binding
GO_0030284Molecular functionnuclear estrogen receptor activity

IV. Literature review

[source]
Gene namePDE3A
Protein namecGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE)
Synonyms
DescriptionFUNCTION: Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes . Has also activity toward cUMP . Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling . .

AccessionsENST00000359062.4
Q14432