CCL2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	37 studies	37% ± 16%	Explore
endothelial cell	22 studies	31% ± 12%	Explore
macrophage	19 studies	29% ± 14%	Explore
smooth muscle cell	17 studies	36% ± 18%	Explore
pericyte	15 studies	46% ± 24%	Explore
endothelial cell of lymphatic vessel	11 studies	31% ± 12%	Explore
connective tissue cell	11 studies	37% ± 15%	Explore
basal cell	10 studies	22% ± 5%	Explore
endothelial cell of vascular tree	9 studies	44% ± 17%	Explore
capillary endothelial cell	9 studies	23% ± 6%	Explore
myeloid cell	8 studies	33% ± 11%	Explore
myofibroblast cell	8 studies	26% ± 11%	Explore
vein endothelial cell	7 studies	33% ± 13%	Explore
endothelial cell of artery	6 studies	24% ± 10%	Explore
monocyte	5 studies	33% ± 16%	Explore
secretory cell	5 studies	31% ± 18%	Explore
adventitial cell	4 studies	28% ± 19%	Explore
mesothelial cell	4 studies	28% ± 9%	Explore
classical monocyte	3 studies	43% ± 25%	Explore
mononuclear phagocyte	3 studies	25% ± 5%	Explore
mast cell	3 studies	18% ± 1%	Explore
muscle cell	3 studies	32% ± 13%	Explore
glial cell	3 studies	37% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	5 studies	22% ± 9%	Explore
prostate	4 studies	22% ± 5%	Explore
intestine	3 studies	31% ± 3%	Explore
uterus	3 studies	32% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	91%	10890.97	525 / 578	93%	71.98	1069 / 1155
kidney	96%	3330.37	85 / 89	86%	120.38	776 / 901
prostate	88%	4403.34	215 / 245	83%	71.18	416 / 502
breast	72%	2187.62	329 / 459	83%	46.01	927 / 1118
pancreas	64%	2102.27	209 / 328	87%	62.05	154 / 178
adrenal gland	96%	3849.36	248 / 258	54%	38.42	124 / 230
intestine	82%	3650.64	796 / 966	62%	29.91	327 / 527
skin	62%	1848.27	1117 / 1809	78%	52.86	369 / 472
thymus	76%	2592.15	496 / 653	59%	23.15	359 / 605
stomach	61%	2996.53	219 / 359	73%	36.49	210 / 286
esophagus	64%	1734.52	923 / 1445	64%	38.73	118 / 183
ovary	24%	420.46	44 / 180	90%	67.46	387 / 430
uterus	34%	692.86	57 / 170	70%	44.88	322 / 459
bladder	33%	3101.14	7 / 21	68%	36.10	342 / 504
lymph node	0%	0	0 / 0	97%	69.62	28 / 29
liver	48%	1040.27	109 / 226	45%	28.12	182 / 406
heart	83%	4518.10	718 / 861	0%	0	0 / 0
brain	16%	421.61	419 / 2642	66%	73.78	464 / 705
adipose	77%	5952.93	925 / 1204	0%	0	0 / 0
blood vessel	73%	3565.01	968 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	69%	27.15	31 / 45
spleen	35%	556.95	85 / 241	0%	0	0 / 0
muscle	12%	187.28	97 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	10%	1.70	8 / 80
peripheral blood	2%	32.50	17 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0019233	Biological process	sensory perception of pain
GO_0043615	Biological process	astrocyte cell migration
GO_0019221	Biological process	cytokine-mediated signaling pathway
GO_0050870	Biological process	positive regulation of T cell activation
GO_0001525	Biological process	angiogenesis
GO_0006954	Biological process	inflammatory response
GO_0051770	Biological process	positive regulation of nitric-oxide synthase biosynthetic process
GO_1904783	Biological process	positive regulation of NMDA glutamate receptor activity
GO_0043547	Biological process	positive regulation of GTPase activity
GO_2000502	Biological process	negative regulation of natural killer cell chemotaxis
GO_0009617	Biological process	response to bacterium
GO_0009887	Biological process	animal organ morphogenesis
GO_1905563	Biological process	negative regulation of vascular endothelial cell proliferation
GO_0007165	Biological process	signal transduction
GO_0071347	Biological process	cellular response to interleukin-1
GO_0006935	Biological process	chemotaxis
GO_0007155	Biological process	cell adhesion
GO_0007010	Biological process	cytoskeleton organization
GO_0019725	Biological process	cellular homeostasis
GO_0006959	Biological process	humoral immune response
GO_0071356	Biological process	cellular response to tumor necrosis factor
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0070098	Biological process	chemokine-mediated signaling pathway
GO_0030335	Biological process	positive regulation of cell migration
GO_2000427	Biological process	positive regulation of apoptotic cell clearance
GO_0048245	Biological process	eosinophil chemotaxis
GO_0007187	Biological process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO_0071222	Biological process	cellular response to lipopolysaccharide
GO_2000134	Biological process	negative regulation of G1/S transition of mitotic cell cycle
GO_0051968	Biological process	positive regulation of synaptic transmission, glutamatergic
GO_0061844	Biological process	antimicrobial humoral immune response mediated by antimicrobial peptide
GO_0008360	Biological process	regulation of cell shape
GO_0034351	Biological process	negative regulation of glial cell apoptotic process
GO_0006468	Biological process	protein phosphorylation
GO_0002548	Biological process	monocyte chemotaxis
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_0019079	Biological process	viral genome replication
GO_0044344	Biological process	cellular response to fibroblast growth factor stimulus
GO_0007259	Biological process	cell surface receptor signaling pathway via JAK-STAT
GO_2000353	Biological process	positive regulation of endothelial cell apoptotic process
GO_0090280	Biological process	positive regulation of calcium ion import
GO_0048246	Biological process	macrophage chemotaxis
GO_0071346	Biological process	cellular response to type II interferon
GO_0007166	Biological process	cell surface receptor signaling pathway
GO_0035684	Biological process	helper T cell extravasation
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0008009	Molecular function	chemokine activity
GO_0048020	Molecular function	CCR chemokine receptor binding
GO_0005102	Molecular function	signaling receptor binding
GO_0031727	Molecular function	CCR2 chemokine receptor binding
GO_0004672	Molecular function	protein kinase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CCL2
Protein name	C-C motif chemokine ligand 2 (Chemokine (C-C motif) ligand 2, isoform CRA_a) C-C motif chemokine 2 (HC11) (Monocyte chemoattractant protein 1) (Monocyte chemotactic and activating factor) (MCAF) (Monocyte chemotactic protein 1) (MCP-1) (Monocyte secretory protein JE) (Small-inducible cytokine A2)
Synonyms	MCP1 hCG_29298 SCYA2
Description	FUNCTION: Acts as a ligand for C-C chemokine receptor CCR2 . Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions . Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils . May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis . .
Accessions	ENST00000580907.6 ENST00000225831.4 J3KRT7 P13500

CCL2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review