RAPGEF4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030073Biological processinsulin secretion
GO_0017156Biological processcalcium-ion regulated exocytosis
GO_0002250Biological processadaptive immune response
GO_0007265Biological processRas protein signal transduction
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0098693Biological processregulation of synaptic vesicle cycle
GO_0017157Biological processregulation of exocytosis
GO_0032024Biological processpositive regulation of insulin secretion
GO_0007189Biological processadenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0098686Cellular componenthippocampal mossy fiber to CA3 synapse
GO_0016020Cellular componentmembrane
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0030552Molecular functioncAMP binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0005515Molecular functionprotein binding
GO_0031267Molecular functionsmall GTPase binding

IV. Literature review

[source]
Gene nameRAPGEF4
Protein nameRap guanine nucleotide exchange factor 4 (cDNA FLJ61771, highly similar to Rap guanine nucleotide exchange factor 4)
RAP guanine nucleotide exchange factor 4 isoform C
Rap guanine nucleotide exchange factor 4
Rap guanine nucleotide exchange factor 4 (Exchange factor directly activated by cAMP 2) (Exchange protein directly activated by cAMP 2) (EPAC 2) (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII)
RAP guanine nucleotide exchange factor 4 isoform B
RAP guanine nucleotide exchange factor 4 isoform A
SynonymsCGEF2
EPAC2
DescriptionFUNCTION: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 (By similarity). .

AccessionsENST00000540783.5 [Q8WZA2-4]
X5D9F4
ENST00000409036.5
ENST00000397085.3
X5D7N4
ENST00000397081.8 [Q8WZA2-1]
ENST00000538974.5 [Q8WZA2-5]
H7BYQ0
B7Z278
E9PB94
ENST00000397087.7 [Q8WZA2-3]
ENST00000535187.5
X5D2S5
Q8WZA2