Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 29 studies | 39% ± 18% | |
oligodendrocyte precursor cell | 14 studies | 53% ± 20% | |
glutamatergic neuron | 12 studies | 61% ± 26% | |
GABAergic neuron | 11 studies | 55% ± 27% | |
neuron | 7 studies | 38% ± 23% | |
adipocyte | 7 studies | 24% ± 6% | |
capillary endothelial cell | 6 studies | 33% ± 13% | |
interneuron | 6 studies | 57% ± 30% | |
retinal cone cell | 6 studies | 57% ± 23% | |
endothelial cell of lymphatic vessel | 6 studies | 48% ± 14% | |
vein endothelial cell | 5 studies | 51% ± 28% | |
endothelial cell of vascular tree | 5 studies | 32% ± 19% | |
granule cell | 4 studies | 49% ± 21% | |
retinal pigment epithelial cell | 4 studies | 42% ± 17% | |
amacrine cell | 4 studies | 36% ± 5% | |
retinal ganglion cell | 4 studies | 44% ± 21% | |
glomerular endothelial cell | 3 studies | 40% ± 5% | |
pericyte | 3 studies | 40% ± 19% | |
GABAergic interneuron | 3 studies | 62% ± 10% | |
microglial cell | 3 studies | 37% ± 20% | |
glycinergic amacrine cell | 3 studies | 33% ± 15% | |
hepatocyte | 3 studies | 37% ± 16% | |
oligodendrocyte | 3 studies | 32% ± 18% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 99% | 19092.26 | 2612 / 2642 | 99% | 37.97 | 698 / 705 |
adrenal gland | 100% | 8520.48 | 258 / 258 | 91% | 21.41 | 210 / 230 |
lung | 97% | 2169.20 | 562 / 578 | 53% | 2.18 | 608 / 1155 |
thymus | 69% | 825.88 | 450 / 653 | 80% | 5.14 | 484 / 605 |
breast | 65% | 749.81 | 299 / 459 | 83% | 5.73 | 924 / 1118 |
liver | 60% | 736.17 | 136 / 226 | 85% | 6.87 | 347 / 406 |
prostate | 47% | 516.38 | 116 / 245 | 81% | 5.45 | 405 / 502 |
kidney | 55% | 659.07 | 49 / 89 | 65% | 8.11 | 588 / 901 |
skin | 63% | 985.26 | 1142 / 1809 | 48% | 5.26 | 225 / 472 |
stomach | 49% | 537.02 | 175 / 359 | 52% | 2.09 | 148 / 286 |
ureter | 0% | 0 | 0 / 0 | 100% | 2.47 | 1 / 1 |
ovary | 77% | 1027.28 | 139 / 180 | 17% | 0.52 | 74 / 430 |
uterus | 60% | 730.35 | 102 / 170 | 34% | 1.26 | 154 / 459 |
esophagus | 13% | 129.61 | 193 / 1445 | 74% | 3.47 | 135 / 183 |
pancreas | 16% | 159.75 | 54 / 328 | 70% | 3.67 | 125 / 178 |
bladder | 33% | 329.90 | 7 / 21 | 41% | 1.67 | 208 / 504 |
eye | 0% | 0 | 0 / 0 | 74% | 13.35 | 59 / 80 |
adipose | 62% | 708.68 | 745 / 1204 | 0% | 0 | 0 / 0 |
intestine | 12% | 115.36 | 112 / 966 | 40% | 1.71 | 209 / 527 |
tonsil | 0% | 0 | 0 / 0 | 38% | 1.09 | 17 / 45 |
heart | 33% | 343.47 | 284 / 861 | 0% | 0 | 0 / 0 |
blood vessel | 7% | 78.07 | 99 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 7% | 0.27 | 2 / 29 |
muscle | 0% | 1.03 | 1 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
GO_0030073 | Biological process | insulin secretion |
GO_0017156 | Biological process | calcium-ion regulated exocytosis |
GO_0002250 | Biological process | adaptive immune response |
GO_0007265 | Biological process | Ras protein signal transduction |
GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
GO_0098693 | Biological process | regulation of synaptic vesicle cycle |
GO_0017157 | Biological process | regulation of exocytosis |
GO_0032024 | Biological process | positive regulation of insulin secretion |
GO_0007189 | Biological process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
GO_0005829 | Cellular component | cytosol |
GO_0005886 | Cellular component | plasma membrane |
GO_0098686 | Cellular component | hippocampal mossy fiber to CA3 synapse |
GO_0016020 | Cellular component | membrane |
GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
GO_0030552 | Molecular function | cAMP binding |
GO_0030674 | Molecular function | protein-macromolecule adaptor activity |
GO_0005515 | Molecular function | protein binding |
GO_0031267 | Molecular function | small GTPase binding |
Gene name | RAPGEF4 |
Protein name | Rap guanine nucleotide exchange factor 4 (cDNA FLJ61771, highly similar to Rap guanine nucleotide exchange factor 4) RAP guanine nucleotide exchange factor 4 isoform C Rap guanine nucleotide exchange factor 4 Rap guanine nucleotide exchange factor 4 (Exchange factor directly activated by cAMP 2) (Exchange protein directly activated by cAMP 2) (EPAC 2) (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) RAP guanine nucleotide exchange factor 4 isoform B RAP guanine nucleotide exchange factor 4 isoform A |
Synonyms | CGEF2 EPAC2 |
Description | FUNCTION: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 (By similarity). . |
Accessions | ENST00000540783.5 [Q8WZA2-4] X5D9F4 ENST00000409036.5 ENST00000397085.3 X5D7N4 ENST00000397081.8 [Q8WZA2-1] ENST00000538974.5 [Q8WZA2-5] H7BYQ0 B7Z278 E9PB94 ENST00000397087.7 [Q8WZA2-3] ENST00000535187.5 X5D2S5 Q8WZA2 |