GPER1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GPER1 at tissue level.

III. Associated gene sets

GO_0002695Biological processnegative regulation of leukocyte activation
GO_0051480Biological processregulation of cytosolic calcium ion concentration
GO_0071389Biological processcellular response to mineralocorticoid stimulus
GO_0006954Biological processinflammatory response
GO_0071392Biological processcellular response to estradiol stimulus
GO_0030264Biological processnuclear fragmentation involved in apoptotic nuclear change
GO_0045742Biological processpositive regulation of epidermal growth factor receptor signaling pathway
GO_0050728Biological processnegative regulation of inflammatory response
GO_0070474Biological processpositive regulation of uterine smooth muscle contraction
GO_0001956Biological processpositive regulation of neurotransmitter secretion
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_2000724Biological processpositive regulation of cardiac vascular smooth muscle cell differentiation
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_2000353Biological processpositive regulation of endothelial cell apoptotic process
GO_0051726Biological processregulation of cell cycle
GO_0090200Biological processpositive regulation of release of cytochrome c from mitochondria
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0071333Biological processcellular response to glucose stimulus
GO_0010948Biological processnegative regulation of cell cycle process
GO_0010629Biological processnegative regulation of gene expression
GO_0045087Biological processinnate immune response
GO_0010628Biological processpositive regulation of gene expression
GO_0045599Biological processnegative regulation of fat cell differentiation
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0032962Biological processpositive regulation of inositol trisphosphate biosynthetic process
GO_0019228Biological processneuronal action potential
GO_0071375Biological processcellular response to peptide hormone stimulus
GO_0043401Biological processsteroid hormone receptor signaling pathway
GO_0007189Biological processadenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0007399Biological processnervous system development
GO_2001238Biological processpositive regulation of extrinsic apoptotic signaling pathway
GO_0070373Biological processnegative regulation of ERK1 and ERK2 cascade
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0032024Biological processpositive regulation of insulin secretion
GO_0007204Biological processpositive regulation of cytosolic calcium ion concentration
GO_0051281Biological processpositive regulation of release of sequestered calcium ion into cytosol
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0042311Biological processvasodilation
GO_0043065Biological processpositive regulation of apoptotic process
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0051055Biological processnegative regulation of lipid biosynthetic process
GO_0030518Biological processnuclear receptor-mediated steroid hormone signaling pathway
GO_1904706Biological processnegative regulation of vascular associated smooth muscle cell proliferation
GO_0050769Biological processpositive regulation of neurogenesis
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0043280Biological processpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0030263Biological processapoptotic chromosome condensation
GO_0045745Biological processpositive regulation of G protein-coupled receptor signaling pathway
GO_0051898Biological processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0071356Biological processcellular response to tumor necrosis factor
GO_1903078Biological processpositive regulation of protein localization to plasma membrane
GO_0030335Biological processpositive regulation of cell migration
GO_0030154Biological processcell differentiation
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0031966Cellular componentmitochondrial membrane
GO_0043679Cellular componentaxon terminus
GO_0098686Cellular componenthippocampal mossy fiber to CA3 synapse
GO_0005802Cellular componenttrans-Golgi network
GO_0032591Cellular componentdendritic spine membrane
GO_0005634Cellular componentnucleus
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0042734Cellular componentpresynaptic membrane
GO_0030425Cellular componentdendrite
GO_0045095Cellular componentkeratin filament
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0044327Cellular componentdendritic spine head
GO_0005886Cellular componentplasma membrane
GO_0055037Cellular componentrecycling endosome
GO_0043198Cellular componentdendritic shaft
GO_0005769Cellular componentearly endosome
GO_0005794Cellular componentGolgi apparatus
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0014069Cellular componentpostsynaptic density
GO_0005737Cellular componentcytoplasm
GO_0030424Cellular componentaxon
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005635Cellular componentnuclear envelope
GO_0048786Cellular componentpresynaptic active zone
GO_0005829Cellular componentcytosol
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0030284Molecular functionnuclear estrogen receptor activity
GO_0003682Molecular functionchromatin binding
GO_0005496Molecular functionsteroid binding
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0005515Molecular functionprotein binding
GO_1990239Molecular functionsteroid hormone binding
GO_0038054Molecular functionG protein-coupled estrogen receptor activity

IV. Literature review

[source]
Gene nameGPER1
Protein nameG-protein coupled estrogen receptor 1 (Chemoattractant receptor-like 2) (Flow-induced endothelial G-protein coupled receptor 1) (FEG-1) (G protein-coupled estrogen receptor 1) (G-protein coupled receptor 30) (GPCR-Br) (IL8-related receptor DRY12) (Lymphocyte-derived G-protein coupled receptor) (LYGPR) (Membrane estrogen receptor) (mER)
G protein-coupled estrogen receptor 1
SynonymsCEPR
CMKRL2
DRY12
GPR30
GPER
DescriptionFUNCTION: G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Functions also as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Involved in cancer progression regulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription factor activating growth regulatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells. .

AccessionsQ99527
ENST00000401670.1
ENST00000397088.4
C9J3W2
ENST00000397092.5
ENST00000297469.3
ENST00000413368.5