FZD7 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FZD7 at tissue level.

III. Associated gene sets

GO_0042327Biological processpositive regulation of phosphorylation
GO_0071300Biological processcellular response to retinoic acid
GO_0060054Biological processpositive regulation of epithelial cell proliferation involved in wound healing
GO_0060231Biological processmesenchymal to epithelial transition
GO_0048103Biological processsomatic stem cell division
GO_0046330Biological processpositive regulation of JNK cascade
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0042666Biological processnegative regulation of ectodermal cell fate specification
GO_0060070Biological processcanonical Wnt signaling pathway
GO_0033077Biological processT cell differentiation in thymus
GO_2000726Biological processnegative regulation of cardiac muscle cell differentiation
GO_0030182Biological processneuron differentiation
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0034446Biological processsubstrate adhesion-dependent cell spreading
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0019827Biological processstem cell population maintenance
GO_0006355Biological processregulation of DNA-templated transcription
GO_0060071Biological processWnt signaling pathway, planar cell polarity pathway
GO_0035567Biological processnon-canonical Wnt signaling pathway
GO_0060828Biological processregulation of canonical Wnt signaling pathway
GO_0010812Biological processnegative regulation of cell-substrate adhesion
GO_0014834Biological processskeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0055038Cellular componentrecycling endosome membrane
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0017147Molecular functionWnt-protein binding
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0005109Molecular functionfrizzled binding
GO_0042813Molecular functionWnt receptor activity
GO_0030165Molecular functionPDZ domain binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFZD7
Protein nameFrizzled-7 (Fz-7) (hFz7) (FzE3)
Synonyms
DescriptionFUNCTION: Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by WNT8 induces expression of beta-catenin target genes (By similarity). Following ligand activation, binds to CCDC88C/DAPLE which displaces DVL1 from FZD7 and leads to inhibition of canonical Wnt signaling, activation of G-proteins by CCDC88C and triggering of non-canonical Wnt responses . May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. .; FUNCTION: (Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium. .

AccessionsO75084
ENST00000286201.3