IL17C report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IL17C at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IL17C at tissue level.

III. Associated gene sets

GO_0006954Biological processinflammatory response
GO_0007267Biological processcell-cell signaling
GO_0007166Biological processcell surface receptor signaling pathway
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameIL17C
Protein nameInterleukin-17C (IL-17C) (Cytokine CX2)
SynonymsUNQ561/PRO1122
DescriptionFUNCTION: Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and pro-inflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases. .

AccessionsENST00000244241.5
Q9P0M4