IL1RAP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006954Biological processinflammatory response
GO_1905606Biological processregulation of presynapse assembly
GO_0032753Biological processpositive regulation of interleukin-4 production
GO_0045087Biological processinnate immune response
GO_0032736Biological processpositive regulation of interleukin-13 production
GO_0099560Biological processsynaptic membrane adhesion
GO_0070498Biological processinterleukin-1-mediated signaling pathway
GO_0038172Biological processinterleukin-33-mediated signaling pathway
GO_0065003Biological processprotein-containing complex assembly
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0006955Biological processimmune response
GO_0032754Biological processpositive regulation of interleukin-5 production
GO_0099545Biological processtrans-synaptic signaling by trans-synaptic complex
GO_0051965Biological processpositive regulation of synapse assembly
GO_0099151Biological processregulation of postsynaptic density assembly
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0098978Cellular componentglutamatergic synapse
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0015026Molecular functioncoreceptor activity
GO_0002114Molecular functioninterleukin-33 receptor activity
GO_0003953Molecular functionNAD+ nucleosidase activity
GO_0005149Molecular functioninterleukin-1 receptor binding
GO_0004908Molecular functioninterleukin-1 receptor activity
GO_0061809Molecular functionNAD+ nucleotidase, cyclic ADP-ribose generating

IV. Literature review

[source]
Gene nameIL1RAP
Protein nameInterleukin 1 receptor accessory protein
Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) (EC 3.2.2.6) (Interleukin-1 receptor 3) (IL-1R-3) (IL-1R3)
SynonymsIL1R3
C3orf13
DescriptionFUNCTION: Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable). .; FUNCTION: [Isoform 2]: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors . Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling (By similarity). .; FUNCTION: [Isoform 4]: Unable to mediate canonical IL-1 signaling . Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons (By similarity). .

AccessionsC9JT28
ENST00000422485.5 [Q9NPH3-2]
ENST00000447382.6 [Q9NPH3-1]
C9J1D9
ENST00000422625.5
Q9NPH3
ENST00000412080.1
ENST00000439062.6 [Q9NPH3-1]
ENST00000072516.7 [Q9NPH3-1]
ENST00000453359.5
C9J9W1
ENST00000342550.6 [Q9NPH3-3]
H7C3W4
ENST00000413869.5 [Q9NPH3-3]
ENST00000434491.5
ENST00000422940.5 [Q9NPH3-2]
ENST00000317757.8 [Q9NPH3-5]