PYDC2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PYDC2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PYDC2 at tissue level.

III. Associated gene sets

GO_0050728Biological processnegative regulation of inflammatory response
GO_0006954Biological processinflammatory response
GO_0010804Biological processnegative regulation of tumor necrosis factor-mediated signaling pathway
GO_1901223Biological processnegative regulation of non-canonical NF-kappaB signal transduction
GO_0032691Biological processnegative regulation of interleukin-1 beta production
GO_1900226Biological processnegative regulation of NLRP3 inflammasome complex assembly
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0045087Biological processinnate immune response
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePYDC2
Protein namePyrin domain-containing protein 2 (Pyrin-only protein 2) (cellular POP2) (cPOP2)
SynonymsPOP2
DescriptionFUNCTION: May play a role in innate immunity by disrupting the interaction between PYCARD and NLRP3, thereby regulating the NLRP3 inflammasome . May also inhibit NF-kappa-B signaling distally by affecting the nuclear accumulation of RELA . .

AccessionsQ56P42
ENST00000518817.1