PIK3CD report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006954Biological processinflammatory response
GO_0001779Biological processnatural killer cell differentiation
GO_0045766Biological processpositive regulation of angiogenesis
GO_0045087Biological processinnate immune response
GO_0002679Biological processrespiratory burst involved in defense response
GO_0007165Biological processsignal transduction
GO_0010595Biological processpositive regulation of endothelial cell migration
GO_0010628Biological processpositive regulation of gene expression
GO_0050853Biological processB cell receptor signaling pathway
GO_0030101Biological processnatural killer cell activation
GO_0030593Biological processneutrophil chemotaxis
GO_0050852Biological processT cell receptor signaling pathway
GO_0038084Biological processvascular endothelial growth factor signaling pathway
GO_0035747Biological processnatural killer cell chemotaxis
GO_0035754Biological processB cell chemotaxis
GO_0048015Biological processphosphatidylinositol-mediated signaling
GO_0043303Biological processmast cell degranulation
GO_0006955Biological processimmune response
GO_0002250Biological processadaptive immune response
GO_0030217Biological processT cell differentiation
GO_0036092Biological processphosphatidylinositol-3-phosphate biosynthetic process
GO_1905278Biological processpositive regulation of epithelial tube formation
GO_0033031Biological processpositive regulation of neutrophil apoptotic process
GO_0001938Biological processpositive regulation of endothelial cell proliferation
GO_0030335Biological processpositive regulation of cell migration
GO_0072672Biological processneutrophil extravasation
GO_0042113Biological processB cell activation
GO_0043491Biological processphosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0016310Biological processphosphorylation
GO_0001819Biological processpositive regulation of cytokine production
GO_0006468Biological processprotein phosphorylation
GO_0010818Biological processT cell chemotaxis
GO_0002551Biological processmast cell chemotaxis
GO_0042110Biological processT cell activation
GO_0016477Biological processcell migration
GO_0030183Biological processB cell differentiation
GO_0060374Biological processmast cell differentiation
GO_0005886Cellular componentplasma membrane
GO_0005942Cellular componentphosphatidylinositol 3-kinase complex
GO_0005943Cellular componentphosphatidylinositol 3-kinase complex, class IA
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005524Molecular functionATP binding
GO_0016301Molecular functionkinase activity
GO_0016303Molecular function1-phosphatidylinositol-3-kinase activity
GO_0035005Molecular function1-phosphatidylinositol-4-phosphate 3-kinase activity
GO_0005515Molecular functionprotein binding
GO_0046934Molecular function1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity

IV. Literature review

[source]
Gene namePIK3CD
Protein namePhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
phosphatidylinositol-4,5-bisphosphate 3-kinase (EC 2.7.1.153)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta)
Synonyms
DescriptionFUNCTION: Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides . Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) . PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Plays a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Plays important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function. Isoform 2 may be involved in stabilizing total RAS levels, resulting in increased ERK phosphorylation and increased PI3K activity. .

AccessionsA0A2K8FKV1
A7E2E0
A0A8V8TNW9
ENST00000698715.1
A0A2K8FKT1
O00329
ENST00000698709.1
ENST00000698710.1
ENST00000698789.1
A0A2K8FKQ1
A0A2K8FKR1
ENST00000698712.1 [O00329-1]
ENST00000361110.6
B7ZM44
F8W9P4
A0A8V8TML5
ENST00000377346.9 [O00329-1]
ENST00000481137.2 [O00329-2]
A0A8V8TM62
ENST00000698714.1
ENST00000698713.1 [O00329-1]
A0A8V8TMM0
ENST00000698716.1
A0A8V8TNP1
ENST00000698707.1