TNIP3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TNIP3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TNIP3 at tissue level.

III. Associated gene sets

GO_0071222Biological processcellular response to lipopolysaccharide
GO_0002756Biological processMyD88-independent toll-like receptor signaling pathway
GO_0006954Biological processinflammatory response
GO_0043124Biological processnegative regulation of canonical NF-kappaB signal transduction
GO_0034142Biological processtoll-like receptor 4 signaling pathway
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005829Cellular componentcytosol
GO_0031593Molecular functionpolyubiquitin modification-dependent protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTNIP3
Protein nameTNFAIP3-interacting protein 3 (A20-binding inhibitor of NF-kappa-B activation 3) (ABIN-3) (Listeria-induced gene protein)
TNFAIP3-interacting protein 3 beta
TNFAIP3 interacting protein 3
SynonymsLIND
ABIN3
DescriptionFUNCTION: Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding. .

AccessionsENST00000509841.1 [Q96KP6-3]
ENST00000515036.1
H0Y9J7
ENST00000057513.8 [Q96KP6-1]
ENST00000507879.5 [Q96KP6-2]
Q96KP6
A5HU65