CYBA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050766Biological processpositive regulation of phagocytosis
GO_0045730Biological processrespiratory burst
GO_0006954Biological processinflammatory response
GO_0045087Biological processinnate immune response
GO_0042554Biological processsuperoxide anion generation
GO_1903428Biological processpositive regulation of reactive oxygen species biosynthetic process
GO_0051649Biological processestablishment of localization in cell
GO_0034137Biological processpositive regulation of toll-like receptor 2 signaling pathway
GO_0050665Biological processhydrogen peroxide biosynthetic process
GO_0051279Biological processregulation of release of sequestered calcium ion into cytosol
GO_0006801Biological processsuperoxide metabolic process
GO_0070254Biological processmucus secretion
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_1900426Biological processpositive regulation of defense response to bacterium
GO_0070257Biological processpositive regulation of mucus secretion
GO_0017004Biological processcytochrome complex assembly
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0014895Biological processsmooth muscle hypertrophy
GO_0035579Cellular componentspecific granule membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0043020Cellular componentNADPH oxidase complex
GO_0070821Cellular componenttertiary granule membrane
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0030141Cellular componentsecretory granule
GO_0005768Cellular componentendosome
GO_0009055Molecular functionelectron transfer activity
GO_0020037Molecular functionheme binding
GO_0046872Molecular functionmetal ion binding
GO_0016175Molecular functionsuperoxide-generating NAD(P)H oxidase activity
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameCYBA
Protein nameCytochrome b-245 alpha chain
Cytochrome b-245 light chain (Cytochrome b(558) alpha chain) (Cytochrome b558 subunit alpha) (Neutrophil cytochrome b 22 kDa polypeptide) (Superoxide-generating NADPH oxidase light chain subunit) (p22 phagocyte B-cytochrome) (p22-phox)
Cytochrome b-245 light chain (Cytochrome b(558) alpha chain) (Cytochrome b558 subunit alpha) (Neutrophil cytochrome b 22 kDa polypeptide) (Superoxide-generating NADPH oxidase light chain subunit) (p22 phagocyte B-cytochrome) (p22-phox) (p22phox)
Flavocytochrome b-558 alpha polypeptide
Synonyms
DescriptionFUNCTION: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. .

FUNCTION: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. .

FUNCTION: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. .

FUNCTION: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. .

FUNCTION: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. .

FUNCTION: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. .

FUNCTION: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. .

FUNCTION: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. .

FUNCTION: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. .

FUNCTION: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. .

FUNCTION: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. .

FUNCTION: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. .

FUNCTION: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. .

AccessionsA0A8Q3SIJ9
P13498
H3BR52
A0A8Q3WL14
ENST00000696157.1
H3BT77
ENST00000567174.5
Q86SL0
A0A8Q3WL27
ENST00000261623.8
A0A8Q3SIH4
A0A8Q3WLM1
ENST00000696161.1
H3BNP7
A0A8Q3WL26
ENST00000696159.1
H3BPX1
ENST00000568278.1
ENST00000565588.6
ENST00000566229.1
ENST00000696156.1
ENST00000569359.5
H3BPZ7
A0A8Q3SJ80
A0A8Q3WL20
ENST00000696163.1
ENST00000696162.1
ENST00000696160.1
ENST00000696158.1