XCL1 | OmnibusX

Name	Number of supported studies	Average coverage
natural killer cell	22 studies	46% ± 22%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	60% ± 18%	Explore
CD8-positive, alpha-beta T cell	11 studies	26% ± 6%	Explore
innate lymphoid cell	8 studies	53% ± 21%	Explore
mature NK T cell	8 studies	46% ± 21%	Explore
gamma-delta T cell	7 studies	46% ± 11%	Explore
T cell	5 studies	21% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	23% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	47% ± 17%	Explore
group 3 innate lymphoid cell	3 studies	46% ± 16%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of XCL1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	98%	66.55	566 / 578	81%	5.04	930 / 1155
uterus	90%	17.66	153 / 170	69%	5.07	315 / 459
esophagus	77%	14.16	1111 / 1445	70%	4.10	128 / 183
thymus	86%	23.62	562 / 653	51%	3.05	309 / 605
kidney	76%	15.42	68 / 89	56%	2.17	509 / 901
stomach	85%	19.51	305 / 359	46%	1.54	132 / 286
liver	87%	38.23	197 / 226	43%	1.69	175 / 406
breast	76%	18.15	350 / 459	52%	1.63	577 / 1118
bladder	57%	23.48	12 / 21	67%	5.08	338 / 504
intestine	84%	24.73	815 / 966	35%	1.19	183 / 527
ovary	46%	6.07	82 / 180	72%	3.67	311 / 430
prostate	82%	15.84	202 / 245	26%	0.52	133 / 502
spleen	100%	236.13	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	18.98	1 / 1
skin	40%	4.82	724 / 1809	54%	2.32	255 / 472
peripheral blood	90%	188.20	834 / 929	0%	0	0 / 0
pancreas	39%	3.98	127 / 328	50%	1.59	89 / 178
lymph node	0%	0	0 / 0	86%	17.08	25 / 29
tonsil	0%	0	0 / 0	82%	2.88	37 / 45
adipose	82%	23.51	983 / 1204	0%	0	0 / 0
heart	67%	11.70	573 / 861	0%	0	0 / 0
blood vessel	63%	15.54	841 / 1335	0%	0	0 / 0
brain	47%	5.57	1230 / 2642	5%	0.10	33 / 705
adrenal gland	30%	2.59	77 / 258	9%	0.23	21 / 230
eye	0%	0	0 / 0	13%	0.42	10 / 80
muscle	6%	0.52	49 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0002826	Biological process	negative regulation of T-helper 1 type immune response
GO_0071636	Biological process	positive regulation of transforming growth factor beta production
GO_0002726	Biological process	positive regulation of T cell cytokine production
GO_0071560	Biological process	cellular response to transforming growth factor beta stimulus
GO_2000556	Biological process	positive regulation of T-helper 1 cell cytokine production
GO_0006954	Biological process	inflammatory response
GO_0002725	Biological process	negative regulation of T cell cytokine production
GO_0032703	Biological process	negative regulation of interleukin-2 production
GO_0043547	Biological process	positive regulation of GTPase activity
GO_0071663	Biological process	positive regulation of granzyme B production
GO_0007165	Biological process	signal transduction
GO_0009615	Biological process	response to virus
GO_0010820	Biological process	positive regulation of T cell chemotaxis
GO_0030593	Biological process	neutrophil chemotaxis
GO_0032733	Biological process	positive regulation of interleukin-10 production
GO_0051209	Biological process	release of sequestered calcium ion into cytosol
GO_2000518	Biological process	negative regulation of T-helper 1 cell activation
GO_0050727	Biological process	regulation of inflammatory response
GO_0071353	Biological process	cellular response to interleukin-4
GO_0035782	Biological process	mature natural killer cell chemotaxis
GO_0043433	Biological process	negative regulation of DNA-binding transcription factor activity
GO_2000553	Biological process	positive regulation of T-helper 2 cell cytokine production
GO_0007267	Biological process	cell-cell signaling
GO_2000538	Biological process	positive regulation of B cell chemotaxis
GO_0001916	Biological process	positive regulation of T cell mediated cytotoxicity
GO_0070098	Biological process	chemokine-mediated signaling pathway
GO_0030335	Biological process	positive regulation of cell migration
GO_2000563	Biological process	positive regulation of CD4-positive, alpha-beta T cell proliferation
GO_2000503	Biological process	positive regulation of natural killer cell chemotaxis
GO_0048245	Biological process	eosinophil chemotaxis
GO_2000566	Biological process	positive regulation of CD8-positive, alpha-beta T cell proliferation
GO_0090023	Biological process	positive regulation of neutrophil chemotaxis
GO_0051281	Biological process	positive regulation of release of sequestered calcium ion into cytosol
GO_0032689	Biological process	negative regulation of type II interferon production
GO_2000513	Biological process	positive regulation of granzyme A production
GO_0061844	Biological process	antimicrobial humoral immune response mediated by antimicrobial peptide
GO_2000558	Biological process	positive regulation of immunoglobulin production in mucosal tissue
GO_2000412	Biological process	positive regulation of thymocyte migration
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0002690	Biological process	positive regulation of leukocyte chemotaxis
GO_2000562	Biological process	negative regulation of CD4-positive, alpha-beta T cell proliferation
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0042803	Molecular function	protein homodimerization activity
GO_0008009	Molecular function	chemokine activity
GO_0048020	Molecular function	CCR chemokine receptor binding
GO_0042379	Molecular function	chemokine receptor binding
GO_0005515	Molecular function	protein binding

Gene name	XCL1
Protein name	Lymphotactin (ATAC) (C motif chemokine 1) (Cytokine SCM-1) (Lymphotaxin) (SCM-1-alpha) (Small-inducible cytokine C1) (XC chemokine ligand 1)
Synonyms	LTN SCYC1
Description	FUNCTION: Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment. .
Accessions	ENST00000367818.4 P47992

XCL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review