SPHK1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SPHK1 at tissue level.

III. Associated gene sets

GO_1903978Biological processregulation of microglial cell activation
GO_0030148Biological processsphingolipid biosynthetic process
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0006670Biological processsphingosine metabolic process
GO_0048146Biological processpositive regulation of fibroblast proliferation
GO_0006954Biological processinflammatory response
GO_0008283Biological processcell population proliferation
GO_0150077Biological processregulation of neuroinflammatory response
GO_0019722Biological processcalcium-mediated signaling
GO_0030307Biological processpositive regulation of cell growth
GO_0045766Biological processpositive regulation of angiogenesis
GO_0010803Biological processregulation of tumor necrosis factor-mediated signaling pathway
GO_0034612Biological processresponse to tumor necrosis factor
GO_0071363Biological processcellular response to growth factor stimulus
GO_1900745Biological processpositive regulation of p38MAPK cascade
GO_0070301Biological processcellular response to hydrogen peroxide
GO_0045931Biological processpositive regulation of mitotic cell cycle
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0003376Biological processsphingosine-1-phosphate receptor signaling pathway
GO_0045987Biological processpositive regulation of smooth muscle contraction
GO_0071897Biological processDNA biosynthetic process
GO_0035556Biological processintracellular signal transduction
GO_0043066Biological processnegative regulation of apoptotic process
GO_0030335Biological processpositive regulation of cell migration
GO_0032651Biological processregulation of interleukin-1 beta production
GO_1900060Biological processnegative regulation of ceramide biosynthetic process
GO_0046512Biological processsphingosine biosynthetic process
GO_0001568Biological processblood vessel development
GO_0030100Biological processregulation of endocytosis
GO_0007420Biological processbrain development
GO_0050764Biological processregulation of phagocytosis
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0016310Biological processphosphorylation
GO_0010800Biological processpositive regulation of peptidyl-threonine phosphorylation
GO_0006473Biological processprotein acetylation
GO_0046521Biological processsphingoid catabolic process
GO_0035924Biological processcellular response to vascular endothelial growth factor stimulus
GO_0045840Biological processpositive regulation of mitotic nuclear division
GO_0032740Biological processpositive regulation of interleukin-17 production
GO_1905364Biological processregulation of endosomal vesicle fusion
GO_0098793Cellular componentpresynapse
GO_0005886Cellular componentplasma membrane
GO_0030139Cellular componentendocytic vesicle
GO_0016020Cellular componentmembrane
GO_0031901Cellular componentearly endosome membrane
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005905Cellular componentclathrin-coated pit
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0051721Molecular functionprotein phosphatase 2A binding
GO_0008289Molecular functionlipid binding
GO_0017050Molecular functionD-erythro-sphingosine kinase activity
GO_0000287Molecular functionmagnesium ion binding
GO_0001727Molecular functionlipid kinase activity
GO_0016407Molecular functionacetyltransferase activity
GO_0008481Molecular functionsphinganine kinase activity
GO_0038036Molecular functionsphingosine-1-phosphate receptor activity
GO_0005524Molecular functionATP binding
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSPHK1
Protein nameSphingosine kinase 1
Sphingosine kinase 1 (cDNA FLJ78254)
SPHK1 protein
Sphingosine kinase 1 (SK 1) (SPK 1) (EC 2.7.1.91) (Acetyltransferase SPHK1) (EC 2.3.1.-)
SynonymshCG_30901
SK1
SPHK
SPK
DescriptionFUNCTION: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol . In contrast to proapoptotic SPHK2, has a negative effect on intracellular ceramide levels, enhances cell growth and inhibits apoptosis . Involved in the regulation of inflammatory response and neuroinflammation. Via the product sphingosine 1-phosphate, stimulates TRAF2 E3 ubiquitin ligase activity, and promotes activation of NF-kappa-B in response to TNF signaling leading to IL17 secretion . In response to TNF and in parallel to NF-kappa-B activation, negatively regulates RANTES induction through p38 MAPK signaling pathway . Involved in endocytic membrane trafficking induced by sphingosine, recruited to dilate endosomes, also plays a role on later stages of endosomal maturation and membrane fusion independently of its kinase activity . In Purkinje cells, seems to be also involved in the regulation of autophagosome-lysosome fusion upon VEGFA . .; FUNCTION: Has serine acetyltransferase activity on PTGS2/COX2 in an acetyl-CoA dependent manner. The acetyltransferase activity increases in presence of the kinase substrate, sphingosine. During neuroinflammation, through PTGS2 acetylation, promotes neuronal secretion of specialized preresolving mediators (SPMs), especially 15-R-lipoxin A4, which results in an increase of phagocytic microglia. .

AccessionsK7EJ32
K7EMA4
ENST00000590379.5
ENST00000588682.5
Q9BTG7
Q53ZR5
Q9NYA1
ENST00000592299.6 [Q9NYA1-1]
ENST00000590959.5 [Q9NYA1-3]
ENST00000545180.5 [Q9NYA1-1]
ENST00000392496.3 [Q9NYA1-1]
ENST00000323374.8 [Q9NYA1-2]