LAT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007265Biological processRas protein signal transduction
GO_0006954Biological processinflammatory response
GO_0019722Biological processcalcium-mediated signaling
GO_0002260Biological processlymphocyte homeostasis
GO_0050852Biological processT cell receptor signaling pathway
GO_0045860Biological processpositive regulation of protein kinase activity
GO_0043303Biological processmast cell degranulation
GO_0006955Biological processimmune response
GO_0002250Biological processadaptive immune response
GO_0007229Biological processintegrin-mediated signaling pathway
GO_0035556Biological processintracellular signal transduction
GO_0050863Biological processregulation of T cell activation
GO_0010467Biological processgene expression
GO_0042110Biological processT cell activation
GO_0001772Cellular componentimmunological synapse
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0016020Cellular componentmembrane
GO_0005794Cellular componentGolgi apparatus
GO_0005911Cellular componentcell-cell junction
GO_0008180Cellular componentCOP9 signalosome
GO_0019901Molecular functionprotein kinase binding
GO_0030159Molecular functionsignaling receptor complex adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLAT
Protein nameLinker for activation of T-cells family member 1
Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38)
Linker for activation of T cells
Linker for activation of T cells (Linker for activation of T-cells family member 1)
Synonyms
DescriptionFUNCTION: Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development . Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. .

AccessionsENST00000564277.5 [O43561-4]
ENST00000570232.2
ENST00000395461.7 [O43561-3]
ENST00000566177.5 [O43561-5]
ENST00000562701.5
ENST00000395456.7 [O43561-2]
ENST00000454369.6 [O43561-4]
C7C5T5
C7C5T7
O43561
H3BQD8
C7C5T8
ENST00000360872.9 [O43561-1]