BLNK | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	34 studies	30% ± 11%	Explore
plasmacytoid dendritic cell	18 studies	44% ± 17%	Explore
naive B cell	17 studies	31% ± 10%	Explore
memory B cell	16 studies	29% ± 8%	Explore
microglial cell	12 studies	43% ± 20%	Explore
plasma cell	11 studies	32% ± 9%	Explore
precursor B cell	6 studies	42% ± 13%	Explore
macrophage	6 studies	31% ± 9%	Explore
pro-B cell	5 studies	42% ± 15%	Explore
epithelial cell	5 studies	28% ± 14%	Explore
plasmablast	4 studies	37% ± 12%	Explore
immature B cell	4 studies	44% ± 9%	Explore
squamous epithelial cell	3 studies	24% ± 7%	Explore
germinal center B cell	3 studies	41% ± 6%	Explore
hepatocyte	3 studies	48% ± 29%	Explore
abnormal cell	3 studies	28% ± 5%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	30% ± 11%	Explore
renal principal cell	3 studies	36% ± 9%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of BLNK at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	631.85	652 / 653	98%	13.02	595 / 605
liver	100%	1629.15	226 / 226	94%	8.55	383 / 406
prostate	92%	502.87	225 / 245	100%	7.95	500 / 502
pancreas	100%	556.80	327 / 328	92%	8.93	163 / 178
kidney	100%	1726.42	89 / 89	88%	7.13	789 / 901
stomach	79%	610.25	282 / 359	91%	8.55	261 / 286
breast	71%	210.45	326 / 459	96%	10.19	1077 / 1118
lung	72%	229.12	419 / 578	89%	6.11	1026 / 1155
intestine	66%	768.75	636 / 966	90%	7.50	475 / 527
bladder	52%	317.00	11 / 21	86%	6.27	431 / 504
esophagus	51%	1023.38	733 / 1445	83%	8.12	151 / 183
skin	72%	386.85	1294 / 1809	38%	2.02	177 / 472
brain	42%	121.98	1110 / 2642	63%	3.45	447 / 705
lymph node	0%	0	0 / 0	100%	58.61	29 / 29
spleen	100%	4284.58	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	3.04	1 / 1
uterus	15%	41.34	26 / 170	81%	7.31	370 / 459
tonsil	0%	0	0 / 0	93%	9.71	42 / 45
peripheral blood	70%	2477.47	647 / 929	0%	0	0 / 0
ovary	7%	10.46	12 / 180	56%	2.22	239 / 430
adipose	55%	128.34	658 / 1204	0%	0	0 / 0
adrenal gland	45%	82.85	116 / 258	6%	0.20	14 / 230
blood vessel	41%	98.37	546 / 1335	0%	0	0 / 0
heart	4%	7.33	38 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	4%	0.12	3 / 80
muscle	1%	2.62	10 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006954	Biological process	inflammatory response
GO_0007169	Biological process	cell surface receptor protein tyrosine kinase signaling pathway
GO_0010628	Biological process	positive regulation of gene expression
GO_0050853	Biological process	B cell receptor signaling pathway
GO_0006959	Biological process	humoral immune response
GO_0035556	Biological process	intracellular signal transduction
GO_0030183	Biological process	B cell differentiation
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0019899	Molecular function	enzyme binding
GO_0008289	Molecular function	lipid binding
GO_0019901	Molecular function	protein kinase binding
GO_1990782	Molecular function	protein tyrosine kinase binding
GO_0005068	Molecular function	transmembrane receptor protein tyrosine kinase adaptor activity
GO_0042169	Molecular function	SH2 domain binding
GO_0035591	Molecular function	signaling adaptor activity
GO_0140693	Molecular function	molecular condensate scaffold activity
GO_0043274	Molecular function	phospholipase binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	BLNK
Protein name	B cell linker B cell linker (B-cell linker protein) B-cell linker protein B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65)
Synonyms	SLP65 BASH
Description	FUNCTION: Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis. .
Accessions	Q2MD40 A0A8Q3WLC4 ENST00000696524.1 ENST00000696514.1 ENST00000696257.1 Q2MD44 Q2MD58 ENST00000696518.1 ENST00000427367.6 ENST00000696517.1 A0A8Q3WLN9 K7EKR2 ENST00000696253.1 ENST00000696248.1 Q2MD50 ENST00000696255.1 ENST00000371176.7 [Q8WV28-2] ENST00000413476.6 [Q8WV28-3] Q2MD48 A0A8Q3SIW1 Q2MD55 Q8WV28 ENST00000696519.1 Q2MD56 A0A8Q3SJD7 ENST00000495266.2 ENST00000696523.1 Q2MD52 Q2MD51 ENST00000696513.1 Q2MD46 Q2MD57 ENST00000696522.1 ENST00000467799.7 ENST00000224337.10 [Q8WV28-1] ENST00000696516.1 A0A8U0WPF8 A0A8Q3SIR3 ENST00000696521.1 Q2MD42 Q2MD47 A0A8Q3WLC3 Q2MD59 Q2MD54

BLNK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review