Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
bladder | 100% | 3117.81 | 21 / 21 | 100% | 63.61 | 503 / 504 |
liver | 100% | 5136.94 | 226 / 226 | 100% | 43.28 | 405 / 406 |
skin | 100% | 5373.88 | 1808 / 1809 | 100% | 64.23 | 471 / 472 |
thymus | 100% | 2770.27 | 651 / 653 | 100% | 46.16 | 605 / 605 |
uterus | 100% | 1921.92 | 170 / 170 | 100% | 64.92 | 457 / 459 |
lung | 100% | 6831.29 | 577 / 578 | 100% | 54.90 | 1151 / 1155 |
intestine | 100% | 3295.25 | 966 / 966 | 99% | 72.89 | 524 / 527 |
prostate | 100% | 3201.05 | 244 / 245 | 100% | 53.12 | 501 / 502 |
stomach | 100% | 3462.74 | 359 / 359 | 99% | 67.84 | 284 / 286 |
breast | 100% | 3351.70 | 459 / 459 | 99% | 44.78 | 1109 / 1118 |
esophagus | 99% | 3620.78 | 1432 / 1445 | 100% | 64.30 | 183 / 183 |
kidney | 100% | 3818.48 | 89 / 89 | 99% | 49.51 | 889 / 901 |
adrenal gland | 100% | 3190.52 | 258 / 258 | 96% | 46.70 | 221 / 230 |
pancreas | 89% | 1416.47 | 293 / 328 | 100% | 72.24 | 178 / 178 |
ovary | 83% | 1185.36 | 149 / 180 | 99% | 45.71 | 427 / 430 |
brain | 60% | 907.11 | 1581 / 2642 | 83% | 17.98 | 586 / 705 |
lymph node | 0% | 0 | 0 / 0 | 100% | 86.09 | 29 / 29 |
spleen | 100% | 6078.27 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 53.19 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 27.41 | 1 / 1 |
peripheral blood | 100% | 14020.93 | 928 / 929 | 0% | 0 | 0 / 0 |
adipose | 100% | 4073.43 | 1202 / 1204 | 0% | 0 | 0 / 0 |
muscle | 100% | 6980.97 | 800 / 803 | 0% | 0 | 0 / 0 |
blood vessel | 99% | 3777.76 | 1327 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 99% | 41.92 | 79 / 80 |
heart | 98% | 4563.07 | 840 / 861 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006954 | Biological process | inflammatory response |
GO_0002931 | Biological process | response to ischemia |
GO_0051770 | Biological process | positive regulation of nitric-oxide synthase biosynthetic process |
GO_0000165 | Biological process | MAPK cascade |
GO_0043536 | Biological process | positive regulation of blood vessel endothelial cell migration |
GO_0007507 | Biological process | heart development |
GO_0007165 | Biological process | signal transduction |
GO_0043410 | Biological process | positive regulation of MAPK cascade |
GO_0072709 | Biological process | cellular response to sorbitol |
GO_0060048 | Biological process | cardiac muscle contraction |
GO_0045860 | Biological process | positive regulation of protein kinase activity |
GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
GO_0001817 | Biological process | regulation of cytokine production |
GO_0071222 | Biological process | cellular response to lipopolysaccharide |
GO_0031098 | Biological process | stress-activated protein kinase signaling cascade |
GO_0090398 | Biological process | cellular senescence |
GO_0038066 | Biological process | p38MAPK cascade |
GO_0035924 | Biological process | cellular response to vascular endothelial growth factor stimulus |
GO_0035331 | Biological process | negative regulation of hippo signaling |
GO_0016020 | Cellular component | membrane |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0004713 | Molecular function | protein tyrosine kinase activity |
GO_0019901 | Molecular function | protein kinase binding |
GO_0004708 | Molecular function | MAP kinase kinase activity |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
Gene name | MAP2K3 |
Protein name | Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2) mitogen-activated protein kinase kinase (EC 2.7.12.2) Mitogen-activated protein kinase kinase 3 |
Synonyms | SKK2 MKK3 PRKMK3 MEK3 |
Description | FUNCTION: Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. . |
Accessions | Q6FHG1 C7DUW4 J3KRV4 ENST00000527123.1 ENST00000316920.10 [P46734-2] ENST00000342679.9 [P46734-1] Q6FI23 E9PRZ0 ENST00000483928.6 ENST00000529517.1 ENST00000627447.1 P46734 ENST00000361818.9 [P46734-2] ENST00000395491.6 ENST00000526076.6 J3QL77 J3QR49 ENST00000479129.5 X6RB39 ENST00000496046.5 E9PMA8 |