MAP2K3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006954Biological processinflammatory response
GO_0002931Biological processresponse to ischemia
GO_0051770Biological processpositive regulation of nitric-oxide synthase biosynthetic process
GO_0000165Biological processMAPK cascade
GO_0043536Biological processpositive regulation of blood vessel endothelial cell migration
GO_0007507Biological processheart development
GO_0007165Biological processsignal transduction
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0072709Biological processcellular response to sorbitol
GO_0060048Biological processcardiac muscle contraction
GO_0045860Biological processpositive regulation of protein kinase activity
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0001817Biological processregulation of cytokine production
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0031098Biological processstress-activated protein kinase signaling cascade
GO_0090398Biological processcellular senescence
GO_0038066Biological processp38MAPK cascade
GO_0035924Biological processcellular response to vascular endothelial growth factor stimulus
GO_0035331Biological processnegative regulation of hippo signaling
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0106310Molecular functionprotein serine kinase activity
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0019901Molecular functionprotein kinase binding
GO_0004708Molecular functionMAP kinase kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMAP2K3
Protein nameDual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2)
mitogen-activated protein kinase kinase (EC 2.7.12.2)
Mitogen-activated protein kinase kinase 3
SynonymsSKK2
MKK3
PRKMK3
MEK3
DescriptionFUNCTION: Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. .

AccessionsQ6FHG1
C7DUW4
J3KRV4
ENST00000527123.1
ENST00000316920.10 [P46734-2]
ENST00000342679.9 [P46734-1]
Q6FI23
E9PRZ0
ENST00000483928.6
ENST00000529517.1
ENST00000627447.1
P46734
ENST00000361818.9 [P46734-2]
ENST00000395491.6
ENST00000526076.6
J3QL77
J3QR49
ENST00000479129.5
X6RB39
ENST00000496046.5
E9PMA8