AGR2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006954Biological processinflammatory response
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0010811Biological processpositive regulation of cell-substrate adhesion
GO_1903896Biological processpositive regulation of IRE1-mediated unfolded protein response
GO_0010628Biological processpositive regulation of gene expression
GO_0048639Biological processpositive regulation of developmental growth
GO_1903078Biological processpositive regulation of protein localization to plasma membrane
GO_0045742Biological processpositive regulation of epidermal growth factor receptor signaling pathway
GO_1903899Biological processpositive regulation of PERK-mediated unfolded protein response
GO_0060480Biological processlung goblet cell differentiation
GO_0070254Biological processmucus secretion
GO_0048546Biological processdigestive tract morphogenesis
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005783Cellular componentendoplasmic reticulum
GO_0005154Molecular functionepidermal growth factor receptor binding
GO_0042802Molecular functionidentical protein binding
GO_0002162Molecular functiondystroglycan binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAGR2
Protein nameAnterior gradient 2, protein disulphide isomerase family member
Anterior gradient protein 2 homolog (AG-2) (hAG-2) (HPC8) (Secreted cement gland protein XAG-2 homolog)
AGR2 (Anterior gradient 2 homolog (Xenopus laevis)) (Anterior gradient 2 splice variant C) (Epididymis secretory protein Li 116)
AGR2
SynonymsHEL-S-116
AG2
tcag7.197
UNQ515/PRO1030
hCG_19292
DescriptionFUNCTION: Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion . .

AccessionsENST00000450569.5
H7C3Z9
Q4JM47
ENST00000419304.7
ENST00000412973.1
C9J3E2
ENST00000401412.5
Q4JM46
O95994
B5MC07