CYP26B1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CYP26B1 at tissue level.

III. Associated gene sets

GO_0071300Biological processcellular response to retinoic acid
GO_0009954Biological processproximal/distal pattern formation
GO_0007283Biological processspermatogenesis
GO_0060349Biological processbone morphogenesis
GO_0006954Biological processinflammatory response
GO_0006766Biological processvitamin metabolic process
GO_0006805Biological processxenobiotic metabolic process
GO_0045580Biological processregulation of T cell differentiation
GO_0070268Biological processcornification
GO_0043587Biological processtongue morphogenesis
GO_0001709Biological processcell fate determination
GO_0061436Biological processestablishment of skin barrier
GO_0010628Biological processpositive regulation of gene expression
GO_0001822Biological processkidney development
GO_0033189Biological processresponse to vitamin A
GO_0048387Biological processnegative regulation of retinoic acid receptor signaling pathway
GO_0016125Biological processsterol metabolic process
GO_0042573Biological processretinoic acid metabolic process
GO_0001768Biological processestablishment of T cell polarity
GO_0030326Biological processembryonic limb morphogenesis
GO_0034653Biological processretinoic acid catabolic process
GO_0048384Biological processretinoic acid receptor signaling pathway
GO_2001037Biological processpositive regulation of tongue muscle cell differentiation
GO_0007140Biological processmale meiotic nuclear division
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005737Cellular componentcytoplasm
GO_0016709Molecular functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO_0062183Molecular functionall-trans retinoic acid 18-hydroxylase activity
GO_0004497Molecular functionmonooxygenase activity
GO_0005506Molecular functioniron ion binding
GO_0008401Molecular functionretinoic acid 4-hydroxylase activity
GO_0020037Molecular functionheme binding
GO_0001972Molecular functionretinoic acid binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCYP26B1
Protein nameCytochrome P450 26B1
Cytochrome P450 family 26 subfamily B member 1
Cytochrome P450 26B1 (EC 1.14.13.-) (Cytochrome P450 26A2) (Cytochrome P450 retinoic acid-inactivating 2) (Cytochrome P450RAI-2) (Retinoic acid-metabolizing cytochrome)
SynonymsCYP26A2
P450RAI2
DescriptionFUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals . RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (Probable). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling . Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination . Involved in the convertion of atRA to all-trans-4-oxo-RA. Can oxidize all-trans-13,14-dihydroretinoate (DRA) to metabolites which could include all-trans-4-oxo-DRA, all-trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all-trans-18-hydroxy-DRA (By similarity). Shows preference for the following substrates: atRA > 9-cis-RA > 13-cis-RA . Plays a central role in germ cell development: acts by degrading RAs in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints . Essential for postnatal survival (By similarity). .; FUNCTION: Has also a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo. .

AccessionsENST00000412253.1
Q9NR63
E7ER08
E5RHM2
ENST00000461519.1
ENST00000001146.7 [Q9NR63-1]
E5RHN4
ENST00000474509.1
ENST00000546307.5 [Q9NR63-2]