Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| mast cell | 16 studies | 31% ± 10% | |
| fibroblast | 12 studies | 19% ± 3% | |
| endothelial cell | 3 studies | 20% ± 2% | |
| capillary endothelial cell | 3 studies | 19% ± 5% | |
| adipocyte | 3 studies | 27% ± 14% |
Insufficient scRNA-seq data for expression of CSF1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 9139.05 | 459 / 459 | 96% | 42.07 | 1074 / 1118 |
| ovary | 99% | 4085.93 | 178 / 180 | 97% | 71.40 | 415 / 430 |
| lung | 100% | 8918.60 | 577 / 578 | 95% | 36.46 | 1094 / 1155 |
| thymus | 99% | 4596.17 | 649 / 653 | 94% | 30.56 | 571 / 605 |
| uterus | 100% | 4553.60 | 170 / 170 | 92% | 31.19 | 423 / 459 |
| esophagus | 97% | 4053.64 | 1400 / 1445 | 93% | 33.72 | 170 / 183 |
| skin | 96% | 8049.75 | 1733 / 1809 | 93% | 41.18 | 438 / 472 |
| kidney | 94% | 3101.61 | 84 / 89 | 93% | 39.69 | 836 / 901 |
| prostate | 99% | 4349.71 | 242 / 245 | 86% | 16.52 | 432 / 502 |
| stomach | 97% | 3442.47 | 348 / 359 | 84% | 27.86 | 240 / 286 |
| intestine | 100% | 5181.12 | 963 / 966 | 77% | 18.58 | 407 / 527 |
| bladder | 100% | 8367.71 | 21 / 21 | 76% | 24.65 | 384 / 504 |
| brain | 67% | 1436.27 | 1760 / 2642 | 99% | 67.38 | 699 / 705 |
| adrenal gland | 99% | 6976.38 | 256 / 258 | 63% | 15.92 | 145 / 230 |
| pancreas | 64% | 1613.89 | 211 / 328 | 93% | 38.51 | 166 / 178 |
| liver | 71% | 1426.23 | 160 / 226 | 72% | 19.72 | 294 / 406 |
| adipose | 100% | 12661.08 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 100% | 9398.91 | 241 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 5828.41 | 1332 / 1335 | 0% | 0 | 0 / 0 |
| heart | 98% | 3304.76 | 847 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 37.21 | 28 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 93% | 32.73 | 42 / 45 |
| eye | 0% | 0 | 0 / 0 | 90% | 21.86 | 72 / 80 |
| muscle | 44% | 893.19 | 357 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 30% | 923.42 | 281 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0010744 | Biological process | positive regulation of macrophage derived foam cell differentiation |
| GO_0001780 | Biological process | neutrophil homeostasis |
| GO_0007265 | Biological process | Ras protein signal transduction |
| GO_1905523 | Biological process | positive regulation of macrophage migration |
| GO_1904141 | Biological process | positive regulation of microglial cell migration |
| GO_0060763 | Biological process | mammary duct terminal end bud growth |
| GO_0006954 | Biological process | inflammatory response |
| GO_0042117 | Biological process | monocyte activation |
| GO_0002931 | Biological process | response to ischemia |
| GO_0007169 | Biological process | cell surface receptor protein tyrosine kinase signaling pathway |
| GO_0045651 | Biological process | positive regulation of macrophage differentiation |
| GO_0051247 | Biological process | positive regulation of protein metabolic process |
| GO_0030316 | Biological process | osteoclast differentiation |
| GO_0060444 | Biological process | branching involved in mammary gland duct morphogenesis |
| GO_0061518 | Biological process | microglial cell proliferation |
| GO_0030225 | Biological process | macrophage differentiation |
| GO_0045087 | Biological process | innate immune response |
| GO_0032946 | Biological process | positive regulation of mononuclear cell proliferation |
| GO_0060611 | Biological process | mammary gland fat development |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0001954 | Biological process | positive regulation of cell-matrix adhesion |
| GO_0038145 | Biological process | macrophage colony-stimulating factor signaling pathway |
| GO_0045657 | Biological process | positive regulation of monocyte differentiation |
| GO_0048873 | Biological process | homeostasis of number of cells within a tissue |
| GO_0045860 | Biological process | positive regulation of protein kinase activity |
| GO_0010759 | Biological process | positive regulation of macrophage chemotaxis |
| GO_0035702 | Biological process | monocyte homeostasis |
| GO_0042488 | Biological process | positive regulation of odontogenesis of dentin-containing tooth |
| GO_0045672 | Biological process | positive regulation of osteoclast differentiation |
| GO_0010743 | Biological process | regulation of macrophage derived foam cell differentiation |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_1902228 | Biological process | positive regulation of macrophage colony-stimulating factor signaling pathway |
| GO_0002158 | Biological process | osteoclast proliferation |
| GO_0061519 | Biological process | macrophage homeostasis |
| GO_0046579 | Biological process | positive regulation of Ras protein signal transduction |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0097529 | Biological process | myeloid leukocyte migration |
| GO_0030278 | Biological process | regulation of ossification |
| GO_0030224 | Biological process | monocyte differentiation |
| GO_0003006 | Biological process | developmental process involved in reproduction |
| GO_0040018 | Biological process | positive regulation of multicellular organism growth |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_1990682 | Cellular component | CSF1-CSF1R complex |
| GO_0005788 | Cellular component | endoplasmic reticulum lumen |
| GO_0016604 | Cellular component | nuclear body |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0005157 | Molecular function | macrophage colony-stimulating factor receptor binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0008083 | Molecular function | growth factor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0005125 | Molecular function | cytokine activity |
| Gene name | CSF1 |
| Protein name | Macrophage colony-stimulating factor 1 (CSF-1) (M-CSF) (MCSF) (Lanimostim) (Proteoglycan macrophage colony-stimulating factor) (PG-M-CSF) [Cleaved into: Processed macrophage colony-stimulating factor 1; Macrophage colony-stimulating factor 1 43 kDa subunit] Colony stimulating factor 1 |
| Synonyms | |
| Description | FUNCTION: Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. . |
| Accessions | ENST00000369801.1 [P09603-2] E9PQ08 E9PJA2 ENST00000329608.11 [P09603-1] ENST00000525659.5 ENST00000369802.7 [P09603-1] ENST00000527192.5 ENST00000357302.8 P09603 ENST00000488198.5 H7BY18 E9PKP4 ENST00000420111.6 [P09603-3] |
