PPBP | OmnibusX

Name	Number of supported studies	Average coverage
platelet	11 studies	84% ± 19%	Explore
megakaryocyte	6 studies	80% ± 19%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of PPBP at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	97%	541.65	558 / 578	31%	3.03	362 / 1155
spleen	100%	1411.02	240 / 241	0%	0	0 / 0
peripheral blood	81%	2821.73	755 / 929	0%	0	0 / 0
intestine	1%	0.46	9 / 966	51%	122.23	267 / 527
thymus	25%	20.50	163 / 653	25%	1.47	149 / 605
liver	41%	33.88	92 / 226	5%	0.30	20 / 406
stomach	2%	2.19	7 / 359	42%	46.26	119 / 286
kidney	17%	12.18	15 / 89	25%	1.06	221 / 901
esophagus	3%	2.24	37 / 1445	34%	4.73	63 / 183
pancreas	0%	0	0 / 328	31%	19.86	55 / 178
bladder	5%	279.19	1 / 21	26%	32.27	130 / 504
brain	2%	1.31	57 / 2642	26%	1.23	180 / 705
adipose	23%	20.23	278 / 1204	0%	0	0 / 0
adrenal gland	3%	1.34	9 / 258	19%	0.79	43 / 230
uterus	2%	1.57	4 / 170	20%	2.26	91 / 459
breast	17%	11.85	76 / 459	3%	0.13	32 / 1118
skin	6%	3.72	110 / 1809	8%	0.51	40 / 472
heart	14%	12.16	117 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	13%	0.55	6 / 45
ovary	1%	0.43	2 / 180	11%	0.27	46 / 430
blood vessel	8%	7.93	106 / 1335	0%	0	0 / 0
muscle	2%	0.80	13 / 803	0%	0	0 / 0
prostate	0%	0.14	1 / 245	1%	0.04	5 / 502
eye	0%	0	0 / 0	1%	0.03	1 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0071222	Biological process	cellular response to lipopolysaccharide
GO_0061844	Biological process	antimicrobial humoral immune response mediated by antimicrobial peptide
GO_0030593	Biological process	neutrophil chemotaxis
GO_0051781	Biological process	positive regulation of cell division
GO_0070098	Biological process	chemokine-mediated signaling pathway
GO_0006954	Biological process	inflammatory response
GO_1904659	Biological process	glucose transmembrane transport
GO_0042742	Biological process	defense response to bacterium
GO_0005615	Cellular component	extracellular space
GO_1904724	Cellular component	tertiary granule lumen
GO_0031093	Cellular component	platelet alpha granule lumen
GO_0005576	Cellular component	extracellular region
GO_0045236	Molecular function	CXCR chemokine receptor binding
GO_0005355	Molecular function	glucose transmembrane transporter activity
GO_0005515	Molecular function	protein binding
GO_0008009	Molecular function	chemokine activity
GO_0008083	Molecular function	growth factor activity

Gene name	PPBP
Protein name	Platelet basic protein (PBP) (C-X-C motif chemokine 7) (Leukocyte-derived growth factor) (LDGF) (Macrophage-derived growth factor) (MDGF) (Small-inducible cytokine B7) [Cleaved into: Connective tissue-activating peptide III (CTAP-III) (LA-PF4) (Low-affinity platelet factor IV); TC-2; Connective tissue-activating peptide III(1-81) (CTAP-III(1-81)); Beta-thromboglobulin (Beta-TG); Neutrophil-activating peptide 2(74) (NAP-2(74)); Neutrophil-activating peptide 2(73) (NAP-2(73)); Neutrophil-activating peptide 2 (NAP-2); TC-1; Neutrophil-activating peptide 2(1-66) (NAP-2(1-66)); Neutrophil-activating peptide 2(1-63) (NAP-2(1-63))]
Synonyms	SCYB7 THBGB1 CTAP3 CXCL7 TGB1
Description	FUNCTION: LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. .
Accessions	ENST00000296028.4 P02775

PPBP report