TNIP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002755Biological processMyD88-dependent toll-like receptor signaling pathway
GO_0006952Biological processdefense response
GO_0045071Biological processnegative regulation of viral genome replication
GO_0006954Biological processinflammatory response
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0006412Biological processtranslation
GO_0070373Biological processnegative regulation of ERK1 and ERK2 cascade
GO_0009101Biological processglycoprotein biosynthetic process
GO_1903003Biological processpositive regulation of protein deubiquitination
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0050729Biological processpositive regulation of inflammatory response
GO_0043124Biological processnegative regulation of canonical NF-kappaB signal transduction
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0007159Biological processleukocyte cell-cell adhesion
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0042802Molecular functionidentical protein binding
GO_0051019Molecular functionmitogen-activated protein kinase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTNIP1
Protein nameTNFAIP3-interacting protein 1 (A20-binding inhibitor of NF-kappa-B activation 1) (ABIN-1) (HIV-1 Nef-interacting protein) (Nef-associated factor 1) (Naf1) (Nip40-1) (Virion-associated nuclear shuttling protein) (VAN) (hVAN)
TNFAIP3 interacting protein 1
SynonymsKIAA0113
NAF1
DescriptionFUNCTION: Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating TAX1BP1 and A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG . Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection. .

AccessionsENST00000517504.5
E7EW15
ENST00000520931.5 [Q15025-3]
ENST00000315050.11 [Q15025-1]
ENST00000519339.5
ENST00000522226.5 [Q15025-1]
ENST00000521001.1
E7EW68
A0A0A0MRZ4
ENST00000524280.5 [Q15025-5]
ENST00000520695.5
Q15025
ENST00000523200.5 [Q15025-4]
E7EWG2
E7EMV7
ENST00000389378.6
ENST00000522100.5
ENST00000523338.5 [Q15025-2]
ENST00000610535.5 [Q15025-4]
H0YC17
ENST00000521591.6 [Q15025-1]
ENST00000610874.4 [Q15025-5]
ENST00000518977.5 [Q15025-2]