Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 21 studies | 29% ± 14% | |
mast cell | 20 studies | 35% ± 16% | |
macrophage | 17 studies | 29% ± 14% | |
oligodendrocyte | 16 studies | 46% ± 18% | |
astrocyte | 12 studies | 31% ± 15% | |
oligodendrocyte precursor cell | 11 studies | 37% ± 18% | |
microglial cell | 10 studies | 32% ± 10% | |
adipocyte | 9 studies | 51% ± 17% | |
myeloid cell | 8 studies | 38% ± 15% | |
dendritic cell | 8 studies | 39% ± 8% | |
GABAergic neuron | 7 studies | 35% ± 19% | |
monocyte | 7 studies | 40% ± 18% | |
alveolar macrophage | 7 studies | 39% ± 22% | |
classical monocyte | 5 studies | 27% ± 8% | |
glutamatergic neuron | 5 studies | 43% ± 24% | |
epithelial cell | 5 studies | 23% ± 5% | |
endothelial cell of lymphatic vessel | 5 studies | 30% ± 10% | |
conventional dendritic cell | 4 studies | 32% ± 15% | |
non-classical monocyte | 4 studies | 23% ± 4% | |
vein endothelial cell | 4 studies | 26% ± 14% | |
fibroblast | 4 studies | 23% ± 6% | |
pericyte | 4 studies | 21% ± 8% | |
interneuron | 4 studies | 45% ± 25% | |
neuron | 3 studies | 21% ± 7% | |
GABAergic interneuron | 3 studies | 23% ± 8% | |
mononuclear phagocyte | 3 studies | 28% ± 5% | |
endothelial cell of vascular tree | 3 studies | 32% ± 14% | |
capillary endothelial cell | 3 studies | 22% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 2083.55 | 2642 / 2642 | 100% | 24.40 | 705 / 705 |
esophagus | 100% | 1474.48 | 1445 / 1445 | 100% | 24.34 | 183 / 183 |
lung | 100% | 3049.44 | 578 / 578 | 100% | 14.30 | 1153 / 1155 |
breast | 100% | 2053.36 | 459 / 459 | 99% | 16.25 | 1109 / 1118 |
prostate | 100% | 1427.87 | 245 / 245 | 99% | 21.17 | 497 / 502 |
uterus | 100% | 1668.52 | 170 / 170 | 99% | 10.66 | 454 / 459 |
intestine | 100% | 1580.48 | 966 / 966 | 99% | 12.69 | 521 / 527 |
stomach | 99% | 872.51 | 357 / 359 | 99% | 15.01 | 284 / 286 |
thymus | 100% | 1376.39 | 652 / 653 | 99% | 7.74 | 596 / 605 |
kidney | 100% | 1226.34 | 89 / 89 | 98% | 12.16 | 884 / 901 |
bladder | 100% | 1215.62 | 21 / 21 | 98% | 11.10 | 494 / 504 |
ovary | 99% | 837.51 | 179 / 180 | 98% | 10.41 | 422 / 430 |
skin | 99% | 1290.07 | 1797 / 1809 | 97% | 18.61 | 457 / 472 |
adrenal gland | 100% | 1069.91 | 258 / 258 | 91% | 10.44 | 210 / 230 |
pancreas | 91% | 591.49 | 300 / 328 | 99% | 12.18 | 176 / 178 |
liver | 78% | 405.57 | 176 / 226 | 61% | 3.78 | 249 / 406 |
adipose | 100% | 2576.58 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 9.35 | 29 / 29 |
spleen | 100% | 2057.15 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 11.86 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.20 | 1 / 1 |
blood vessel | 100% | 1076.44 | 1332 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 96% | 11.59 | 77 / 80 |
heart | 96% | 810.66 | 827 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 95% | 1731.82 | 879 / 929 | 0% | 0 | 0 / 0 |
muscle | 57% | 265.17 | 459 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0008284 | Biological process | positive regulation of cell population proliferation |
GO_0043067 | Biological process | regulation of programmed cell death |
GO_0006954 | Biological process | inflammatory response |
GO_0071602 | Biological process | phytosphingosine biosynthetic process |
GO_0042552 | Biological process | myelination |
GO_0046512 | Biological process | sphingosine biosynthetic process |
GO_0046514 | Biological process | ceramide catabolic process |
GO_0000139 | Cellular component | Golgi membrane |
GO_0016020 | Cellular component | membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0017040 | Molecular function | N-acylsphingosine amidohydrolase activity |
GO_0070774 | Molecular function | phytoceramidase activity |
GO_0005509 | Molecular function | calcium ion binding |
GO_0102121 | Molecular function | ceramidase activity |
GO_0071633 | Molecular function | dihydroceramidase activity |
GO_0008270 | Molecular function | zinc ion binding |
Gene name | ACER3 |
Protein name | Alkaline ceramidase (EC 3.5.1.-) Alternative protein ACER3 Alkaline ceramidase 3 (AlkCDase 3) (Alkaline CDase 3) (EC 3.5.1.-) (EC 3.5.1.23) (Alkaline dihydroceramidase SB89) (Alkaline phytoceramidase) (aPHC) |
Synonyms | PHCA APHC |
Description | FUNCTION: Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4-ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH . Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation . Controls the generation of sphingosine in erythrocytes, and thereby sphingosine-1-phosphate in plasma . Through the regulation of ceramides and sphingosine-1-phosphate homeostasis in the brain may play a role in neurons survival and function (By similarity). By regulating the levels of pro-inflammatory ceramides in immune cells and tissues, may modulate the inflammatory response (By similarity). . FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. . FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. . FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. . FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. . FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. . FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. . FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. . FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. . FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. . FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. . FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. . FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. . FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. . FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. . FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. . |
Accessions | ENST00000681375.1 ENST00000680842.1 ENST00000531352.5 ENST00000679754.1 ENST00000681411.1 ENST00000680583.1 Q9NUN7 A0A7P0TAT0 ENST00000525861.5 J3KN85 E9PR08 ENST00000679866.1 A0A7P0T836 ENST00000533873.1 ENST00000278544.9 A0A7P0T842 E9PIN9 ENST00000681004.1 E9PLZ9 A0A7P0T8K3 A0A7P0Z4N4 ENST00000681955.1 ENST00000681354.1 L8E8G3 ENST00000681251.1 A0A7P0T912 ENST00000526597.5 B7Z2Q2 ENST00000534206.5 B7Z2V2 ENST00000530334.6 A0A7P0TAD8 ENST00000681257.1 ENST00000531461.5 E9PL35 ENST00000681732.1 ENST00000532485.6 [Q9NUN7-1] ENST00000525194.5 E9PKR3 ENST00000679924.1 |