ACER3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008284Biological processpositive regulation of cell population proliferation
GO_0043067Biological processregulation of programmed cell death
GO_0006954Biological processinflammatory response
GO_0071602Biological processphytosphingosine biosynthetic process
GO_0042552Biological processmyelination
GO_0046512Biological processsphingosine biosynthetic process
GO_0046514Biological processceramide catabolic process
GO_0000139Cellular componentGolgi membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0017040Molecular functionN-acylsphingosine amidohydrolase activity
GO_0070774Molecular functionphytoceramidase activity
GO_0005509Molecular functioncalcium ion binding
GO_0102121Molecular functionceramidase activity
GO_0071633Molecular functiondihydroceramidase activity
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameACER3
Protein nameAlkaline ceramidase (EC 3.5.1.-)
Alternative protein ACER3
Alkaline ceramidase 3 (AlkCDase 3) (Alkaline CDase 3) (EC 3.5.1.-) (EC 3.5.1.23) (Alkaline dihydroceramidase SB89) (Alkaline phytoceramidase) (aPHC)
SynonymsPHCA
APHC
DescriptionFUNCTION: Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4-ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH . Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation . Controls the generation of sphingosine in erythrocytes, and thereby sphingosine-1-phosphate in plasma . Through the regulation of ceramides and sphingosine-1-phosphate homeostasis in the brain may play a role in neurons survival and function (By similarity). By regulating the levels of pro-inflammatory ceramides in immune cells and tissues, may modulate the inflammatory response (By similarity). .

FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. .

FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. .

FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. .

FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. .

FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. .

FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. .

FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. .

FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. .

FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. .

FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. .

FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. .

FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. .

FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. .

FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. .

FUNCTION: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. .

AccessionsENST00000681375.1
ENST00000680842.1
ENST00000531352.5
ENST00000679754.1
ENST00000681411.1
ENST00000680583.1
Q9NUN7
A0A7P0TAT0
ENST00000525861.5
J3KN85
E9PR08
ENST00000679866.1
A0A7P0T836
ENST00000533873.1
ENST00000278544.9
A0A7P0T842
E9PIN9
ENST00000681004.1
E9PLZ9
A0A7P0T8K3
A0A7P0Z4N4
ENST00000681955.1
ENST00000681354.1
L8E8G3
ENST00000681251.1
A0A7P0T912
ENST00000526597.5
B7Z2Q2
ENST00000534206.5
B7Z2V2
ENST00000530334.6
A0A7P0TAD8
ENST00000681257.1
ENST00000531461.5
E9PL35
ENST00000681732.1
ENST00000532485.6 [Q9NUN7-1]
ENST00000525194.5
E9PKR3
ENST00000679924.1