Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 39 studies | 35% ± 14% | |
classical monocyte | 26 studies | 42% ± 15% | |
non-classical monocyte | 24 studies | 63% ± 14% | |
monocyte | 23 studies | 45% ± 14% | |
conventional dendritic cell | 23 studies | 38% ± 12% | |
dendritic cell | 19 studies | 36% ± 15% | |
myeloid cell | 16 studies | 37% ± 12% | |
microglial cell | 13 studies | 37% ± 15% | |
neutrophil | 10 studies | 36% ± 17% | |
alveolar macrophage | 7 studies | 30% ± 10% | |
mononuclear phagocyte | 6 studies | 38% ± 19% | |
brush cell | 5 studies | 70% ± 18% | |
B cell | 5 studies | 24% ± 8% | |
leukocyte | 4 studies | 27% ± 10% | |
precursor B cell | 4 studies | 39% ± 17% | |
intermediate monocyte | 4 studies | 61% ± 19% | |
immature B cell | 3 studies | 30% ± 14% | |
tissue-resident macrophage | 3 studies | 35% ± 5% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
peripheral blood | 9 studies | 22% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 100% | 3634.74 | 578 / 578 | 96% | 40.95 | 1106 / 1155 |
breast | 90% | 589.58 | 411 / 459 | 95% | 22.57 | 1064 / 1118 |
intestine | 87% | 762.52 | 841 / 966 | 79% | 15.70 | 417 / 527 |
bladder | 90% | 543.71 | 19 / 21 | 70% | 17.84 | 351 / 504 |
kidney | 52% | 333.11 | 46 / 89 | 90% | 22.61 | 808 / 901 |
esophagus | 60% | 312.46 | 870 / 1445 | 80% | 14.75 | 147 / 183 |
adrenal gland | 91% | 794.92 | 236 / 258 | 47% | 5.36 | 107 / 230 |
stomach | 54% | 336.18 | 193 / 359 | 83% | 17.65 | 238 / 286 |
uterus | 51% | 231.24 | 86 / 170 | 86% | 19.08 | 393 / 459 |
brain | 41% | 252.48 | 1076 / 2642 | 94% | 25.44 | 664 / 705 |
prostate | 72% | 409.39 | 176 / 245 | 62% | 6.47 | 311 / 502 |
skin | 49% | 195.44 | 878 / 1809 | 85% | 22.91 | 402 / 472 |
thymus | 52% | 261.59 | 341 / 653 | 78% | 20.82 | 473 / 605 |
pancreas | 24% | 118.69 | 80 / 328 | 91% | 24.35 | 162 / 178 |
ovary | 34% | 141.63 | 62 / 180 | 77% | 12.61 | 329 / 430 |
liver | 51% | 317.67 | 115 / 226 | 55% | 7.85 | 225 / 406 |
lymph node | 0% | 0 | 0 / 0 | 100% | 164.94 | 29 / 29 |
spleen | 100% | 11245.78 | 241 / 241 | 0% | 0 | 0 / 0 |
adipose | 98% | 1258.36 | 1180 / 1204 | 0% | 0 | 0 / 0 |
peripheral blood | 98% | 37188.62 | 907 / 929 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 96% | 38.12 | 43 / 45 |
blood vessel | 70% | 579.70 | 931 / 1335 | 0% | 0 | 0 / 0 |
heart | 52% | 263.59 | 445 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 39% | 4.77 | 31 / 80 |
muscle | 6% | 20.14 | 50 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0032956 | Biological process | regulation of actin cytoskeleton organization |
GO_0031663 | Biological process | lipopolysaccharide-mediated signaling pathway |
GO_0019221 | Biological process | cytokine-mediated signaling pathway |
GO_0007498 | Biological process | mesoderm development |
GO_0030838 | Biological process | positive regulation of actin filament polymerization |
GO_0002522 | Biological process | leukocyte migration involved in immune response |
GO_0071801 | Biological process | regulation of podosome assembly |
GO_0006954 | Biological process | inflammatory response |
GO_0007169 | Biological process | cell surface receptor protein tyrosine kinase signaling pathway |
GO_0045087 | Biological process | innate immune response |
GO_0045728 | Biological process | respiratory burst after phagocytosis |
GO_0002758 | Biological process | innate immune response-activating signaling pathway |
GO_0060333 | Biological process | type II interferon-mediated signaling pathway |
GO_0002862 | Biological process | negative regulation of inflammatory response to antigenic stimulus |
GO_0007155 | Biological process | cell adhesion |
GO_0050727 | Biological process | regulation of inflammatory response |
GO_0018108 | Biological process | peptidyl-tyrosine phosphorylation |
GO_0007229 | Biological process | integrin-mediated signaling pathway |
GO_0035556 | Biological process | intracellular signal transduction |
GO_0043066 | Biological process | negative regulation of apoptotic process |
GO_0030154 | Biological process | cell differentiation |
GO_0008284 | Biological process | positive regulation of cell population proliferation |
GO_0008360 | Biological process | regulation of cell shape |
GO_0050764 | Biological process | regulation of phagocytosis |
GO_0051090 | Biological process | regulation of DNA-binding transcription factor activity |
GO_0006468 | Biological process | protein phosphorylation |
GO_0046777 | Biological process | protein autophosphorylation |
GO_0043299 | Biological process | leukocyte degranulation |
GO_0038096 | Biological process | Fc-gamma receptor signaling pathway involved in phagocytosis |
GO_0005886 | Cellular component | plasma membrane |
GO_0009898 | Cellular component | cytoplasmic side of plasma membrane |
GO_0005764 | Cellular component | lysosome |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0005884 | Cellular component | actin filament |
GO_0005925 | Cellular component | focal adhesion |
GO_0005829 | Cellular component | cytosol |
GO_0030133 | Cellular component | transport vesicle |
GO_0042995 | Cellular component | cell projection |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0005901 | Cellular component | caveola |
GO_0005634 | Cellular component | nucleus |
GO_0004715 | Molecular function | non-membrane spanning protein tyrosine kinase activity |
GO_0008289 | Molecular function | lipid binding |
GO_0004713 | Molecular function | protein tyrosine kinase activity |
GO_0005102 | Molecular function | signaling receptor binding |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
GO_0001784 | Molecular function | phosphotyrosine residue binding |
Gene name | HCK |
Protein name | Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck) Tyrosine-protein kinase (EC 2.7.10.2) HCK proto-oncogene, Src family tyrosine kinase |
Synonyms | |
Description | FUNCTION: Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS. . |
Accessions | P08631 ENST00000375862.7 [P08631-4] ENST00000375862 ENST00000262651.4 H0Y3C5 ENST00000518730.5 [P08631-3] ENST00000629881.2 [P08631-2] J3KPD6 H7C5P9 ENST00000486475.6 H7BXG4 ENST00000520553.5 [P08631-2] ENST00000375852 ENST00000375852.5 [P08631-1] |