HCK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032956Biological processregulation of actin cytoskeleton organization
GO_0031663Biological processlipopolysaccharide-mediated signaling pathway
GO_0019221Biological processcytokine-mediated signaling pathway
GO_0007498Biological processmesoderm development
GO_0030838Biological processpositive regulation of actin filament polymerization
GO_0002522Biological processleukocyte migration involved in immune response
GO_0071801Biological processregulation of podosome assembly
GO_0006954Biological processinflammatory response
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0045087Biological processinnate immune response
GO_0045728Biological processrespiratory burst after phagocytosis
GO_0002758Biological processinnate immune response-activating signaling pathway
GO_0060333Biological processtype II interferon-mediated signaling pathway
GO_0002862Biological processnegative regulation of inflammatory response to antigenic stimulus
GO_0007155Biological processcell adhesion
GO_0050727Biological processregulation of inflammatory response
GO_0018108Biological processpeptidyl-tyrosine phosphorylation
GO_0007229Biological processintegrin-mediated signaling pathway
GO_0035556Biological processintracellular signal transduction
GO_0043066Biological processnegative regulation of apoptotic process
GO_0030154Biological processcell differentiation
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0008360Biological processregulation of cell shape
GO_0050764Biological processregulation of phagocytosis
GO_0051090Biological processregulation of DNA-binding transcription factor activity
GO_0006468Biological processprotein phosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0043299Biological processleukocyte degranulation
GO_0038096Biological processFc-gamma receptor signaling pathway involved in phagocytosis
GO_0005886Cellular componentplasma membrane
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0005764Cellular componentlysosome
GO_0005794Cellular componentGolgi apparatus
GO_0005884Cellular componentactin filament
GO_0005925Cellular componentfocal adhesion
GO_0005829Cellular componentcytosol
GO_0030133Cellular componenttransport vesicle
GO_0042995Cellular componentcell projection
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005901Cellular componentcaveola
GO_0005634Cellular componentnucleus
GO_0004715Molecular functionnon-membrane spanning protein tyrosine kinase activity
GO_0008289Molecular functionlipid binding
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0005102Molecular functionsignaling receptor binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0001784Molecular functionphosphotyrosine residue binding

IV. Literature review

[source]
Gene nameHCK
Protein nameTyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)
Tyrosine-protein kinase (EC 2.7.10.2)
HCK proto-oncogene, Src family tyrosine kinase
Synonyms
DescriptionFUNCTION: Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS. .

AccessionsP08631
ENST00000375862.7 [P08631-4]
ENST00000375862
ENST00000262651.4
H0Y3C5
ENST00000518730.5 [P08631-3]
ENST00000629881.2 [P08631-2]
J3KPD6
H7C5P9
ENST00000486475.6
H7BXG4
ENST00000520553.5 [P08631-2]
ENST00000375852
ENST00000375852.5 [P08631-1]