BCL6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035024Biological processnegative regulation of Rho protein signal transduction
GO_0006366Biological processtranscription by RNA polymerase II
GO_0048870Biological processcell motility
GO_0042092Biological processtype 2 immune response
GO_0048821Biological processerythrocyte development
GO_0043380Biological processregulation of memory T cell differentiation
GO_0007283Biological processspermatogenesis
GO_0006954Biological processinflammatory response
GO_0007160Biological processcell-matrix adhesion
GO_0002467Biological processgerminal center formation
GO_0002634Biological processregulation of germinal center formation
GO_0042129Biological processregulation of T cell proliferation
GO_0006974Biological processDNA damage response
GO_0001953Biological processnegative regulation of cell-matrix adhesion
GO_0002903Biological processnegative regulation of B cell apoptotic process
GO_2000147Biological processpositive regulation of cell motility
GO_0048289Biological processisotype switching to IgE isotypes
GO_0045629Biological processnegative regulation of T-helper 2 cell differentiation
GO_1903464Biological processnegative regulation of mitotic cell cycle DNA replication
GO_0002682Biological processregulation of immune system process
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0050727Biological processregulation of inflammatory response
GO_0050776Biological processregulation of immune response
GO_0045064Biological processT-helper 2 cell differentiation
GO_0031507Biological processheterochromatin formation
GO_0030036Biological processactin cytoskeleton organization
GO_0032764Biological processnegative regulation of mast cell cytokine production
GO_0021859Biological processpyramidal neuron differentiation
GO_0045595Biological processregulation of cell differentiation
GO_0030890Biological processpositive regulation of B cell proliferation
GO_0001817Biological processregulation of cytokine production
GO_0002317Biological processplasma cell differentiation
GO_0007266Biological processRho protein signal transduction
GO_0042100Biological processB cell proliferation
GO_0008104Biological processprotein localization
GO_0000902Biological processcell morphogenesis
GO_0045666Biological processpositive regulation of neuron differentiation
GO_0048294Biological processnegative regulation of isotype switching to IgE isotypes
GO_0045746Biological processnegative regulation of Notch signaling pathway
GO_0043065Biological processpositive regulation of apoptotic process
GO_0045591Biological processpositive regulation of regulatory T cell differentiation
GO_1900099Biological processnegative regulation of plasma cell differentiation
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0042127Biological processregulation of cell population proliferation
GO_2000773Biological processnegative regulation of cellular senescence
GO_0032945Biological processnegative regulation of mononuclear cell proliferation
GO_0030308Biological processnegative regulation of cell growth
GO_0005730Cellular componentnucleolus
GO_0005657Cellular componentreplication fork
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0042382Cellular componentparaspeckles
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0003682Molecular functionchromatin binding
GO_0001161Molecular functionintronic transcription regulatory region sequence-specific DNA binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0001222Molecular functiontranscription corepressor binding
GO_0042802Molecular functionidentical protein binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0046872Molecular functionmetal ion binding
GO_0031490Molecular functionchromatin DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBCL6
Protein nameB-cell lymphoma 6 protein (BCL-6) (B-cell lymphoma 5 protein) (BCL-5) (Protein LAZ-3) (Zinc finger and BTB domain-containing protein 27) (Zinc finger protein 51)
Zinc finger transcription factor BCL6S
B-cell CLL/lymphoma 6
BCL6 protein
BCL6 transcription repressor
SynonymsBCL5
ZNF51
ZBTB27
LAZ3
DescriptionFUNCTION: Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation. .

AccessionsA0N7C7
P41182
ENST00000419510.6
Q16413
C9JCS5
ENST00000438077.1
A0A0C4DH53
A0N7C6
ENST00000450123.6 [P41182-2]
B5B0A5
ENST00000430339.5
ENST00000621333.4 [P41182-2]
A5PL18
ENST00000406870.7 [P41182-1]
C9JL16
ENST00000232014.8 [P41182-1]